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兔外周血淋巴细胞的膜相关免疫球蛋白：b位点的等位基因排斥

Membrane-associated immunoglobulin of rabbit peripheral blood lymphocytes: allelic exclusion at the b locus.

作者信息

Davie J M, Paul W E, Mage R G, Goldman M B

出版信息

Proc Natl Acad Sci U S A. 1971 Feb;68(2):430-4. doi: 10.1073/pnas.68.2.430.

DOI:10.1073/pnas.68.2.430
PMID:4100380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388954/
Abstract

Light chain allotypic determinants were demonstrated on the surface of peripheral blood lymphocytes of rabbits. By means of a combined immunofluorescent and autoradiographic technique, a great majority of the individual lymphocytes of rabbits heteroxygous at the b locus were shown to have detectable quantities of only one allotype. A small proportion of lymphocytes appeared to possess both allelic forms of L chains.

摘要

在兔外周血淋巴细胞表面证实有轻链同种异型决定簇。通过免疫荧光和放射自显影相结合的技术，发现b位点杂合的兔的绝大多数单个淋巴细胞仅含有可检测量的一种同种异型。一小部分淋巴细胞似乎同时拥有L链的两种等位基因形式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0c/388954/a76731cabd79/pnas00077-0187-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0c/388954/d18596f99736/pnas00077-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0c/388954/a76731cabd79/pnas00077-0187-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0c/388954/d18596f99736/pnas00077-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb0c/388954/a76731cabd79/pnas00077-0187-b.jpg

相似文献

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Membrane-associated immunoglobulin of rabbit peripheral blood lymphocytes: allelic exclusion at the b locus.兔外周血淋巴细胞的膜相关免疫球蛋白：b位点的等位基因排斥
Proc Natl Acad Sci U S A. 1971 Feb;68(2):430-4. doi: 10.1073/pnas.68.2.430.
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本文引用的文献

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STUDIES ON RABBIT LYMPHOCYTES IN VITRO. I. STIMULATION OF BLAST TRANSFORMATION WITH AN ANTIALLOTYPE SERUM.家兔淋巴细胞的体外研究。I. 用抗独特型血清刺激母细胞转化
J Exp Med. 1965 Aug 1;122(2):423-40. doi: 10.1084/jem.122.2.423.
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THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
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IMMUNOCHEMICAL IDENTIFICATION AND GENETICS OF RABBIT GAMMA-GLOBULIN ALLOTYPES.兔γ-球蛋白同种异型的免疫化学鉴定与遗传学
正常及同种异型抑制杂合兔细胞表面和血清免疫球蛋白中κ链同种异型的表达。
Immunology. 1982 Jul;46(3):661-9.
4
Specific binding of antigen to lymphocytes. Evidence for lack of unispecificity in antigen-binding cells.抗原与淋巴细胞的特异性结合。抗原结合细胞缺乏单特异性的证据。
Am J Pathol. 1971 Nov;65(2):451-65.
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Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs.免疫活性细胞上的受体。II. 正常豚鼠二硝基苯基化豚鼠白蛋白-125I结合淋巴细胞上受体的特异性和性质。
J Exp Med. 1971 Aug 1;134(2):495-516. doi: 10.1084/jem.134.2.495.
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Restriction of gene expression in B lymphocytes and their progeny. I. Commitment to immunoglobulin allotype.B淋巴细胞及其后代中基因表达的限制。I. 对免疫球蛋白同种异型的定向。
J Exp Med. 1974 Mar 1;139(3):581-99. doi: 10.1084/jem.139.3.581.
7
Class, subclass, and allelic exclusion of membrane-bound Ig of human B lymphocytes.人类B淋巴细胞膜结合免疫球蛋白的类别、亚类和等位基因排斥
J Exp Med. 1972 Aug 1;136(2):409-14. doi: 10.1084/jem.136.2.409.
8
The origin of cell surface immunoglobulin of marrow-derived and thymus-derived lymphocytes of the rat.大鼠骨髓来源和胸腺来源淋巴细胞的细胞表面免疫球蛋白的起源
J Exp Med. 1974 Mar 1;139(3):479-96. doi: 10.1084/jem.139.3.479.
9
Immune responses in vitro. IV. Suppression of primary M, G, and A plaque-forming cell responses in mouse spleen cell cultures by class-specific antibody to mouse immunoglobulins.体外免疫反应。IV. 用小鼠免疫球蛋白的类特异性抗体抑制小鼠脾细胞培养物中初级M、G和A斑块形成细胞反应。
J Exp Med. 1972 Mar 1;135(3):675-97. doi: 10.1084/jem.135.3.675.
10
Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.抗半抗原抗体反应中的载体功能。IV. 诱导半抗原特异性耐受或通过“非免疫原性”半抗原-多肽偶联物刺激抗半抗原回忆反应的实验条件。
J Exp Med. 1971 Jul 1;134(1):201-23. doi: 10.1084/jem.134.1.201.
J Immunol. 1963 Sep;91:403-15.
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A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY.一种制备荧光抗体的透析技术。
Virology. 1963 Aug;20:642-4. doi: 10.1016/0042-6822(63)90292-7.
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Studies on rabbit lymphocytes in vitro. XI. Superaddition of anti-allotypic lymphocyte transformation: evidence for multipotent lymphoid cells.兔淋巴细胞的体外研究。十一。抗同种异型淋巴细胞转化的叠加：多能淋巴细胞的证据。
J Immunol. 1970 Jan;104(1):103-13.
6
Rabbit light chains lacking b-allotypic specificites. I. Isolation and characterization of light chains from normal and allotype suppressed homozygotes.缺乏b等位基因特异性的兔轻链。I. 来自正常和等位基因抑制纯合子的轻链的分离与特性分析。
J Immunol. 1969 Mar;102(3):638-46.
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Immunoglobulin spots on the surface of rabbit lymphocytes.兔淋巴细胞表面的免疫球蛋白斑点。
J Exp Med. 1970 Nov;132(5):1001-18. doi: 10.1084/jem.132.5.1001.
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Immunoglobulin allotypic determinants on rabbit lymphocytes.兔淋巴细胞上的免疫球蛋白同种异型决定簇。
Nature. 1970 Sep 5;227(5262):1051-3. doi: 10.1038/2271051a0.
9
Absence of gamma-globulin receptors on mouse plasmacytoma cells.小鼠浆细胞瘤细胞上缺乏γ-球蛋白受体。
Nature. 1970 Jul 25;227(5256):395-7. doi: 10.1038/227395a0.
10
Immunoglobulin determinants on the lymphocytes of normal rabbits. I. Demonstration by the mixed antiglobulin reaction of determinants recognized by anti-gamma, anti-mu, anti-Fab and anti-allotype sera, anti-As4 and anti-As6.正常兔淋巴细胞上的免疫球蛋白决定簇。I. 通过混合抗球蛋白反应证明抗γ、抗μ、抗Fab、抗同种异型血清、抗As4和抗As6所识别的决定簇
Immunology. 1970 Mar;18(3):417-29.