Lorenzett Ariane Krause Padilha, Lima Vanderlei Aparecido de, Fonseca Clovis Orlando Pereira da, Mainardes Rubiana Mara
Laboratory of Nanostructured Formulations, Universidade Estadual do Centro-Oeste, Alameda Élio Antonio Dalla Vecchia St., 838, Guarapuava 85040-167, PR, Brazil.
Chemistry Department, Federal Technological University of Paraná UTFPR, Via do Conhecimento, s/n, KM 01, Fraron, Pato Branco 85503-390, PR, Brazil.
Pharmaceutics. 2025 Aug 25;17(9):1104. doi: 10.3390/pharmaceutics17091104.
: Nanoemulsions and microemulsions are promising drug delivery systems capable of enhancing the solubility, stability, and bioavailability of active pharmaceutical ingredients, particularly for central nervous system (CNS) disorders. This study presents a bibliometric analysis of scientific publications on intranasal nanoemulsions from 2004 to 2024, based on data from the Scopus database. : A total of 379 articles were analyzed using Bibliometrix and VOSviewer to identify publication trends, leading countries and institutions, prominent journals, and keyword networks. Publications grew significantly over the last decade, with India, the United States, and China leading in volume. Keyword analysis revealed strong thematic clusters related to "brain targeting," "drug delivery," and "intranasal administration," highlighting this route's potential for bypassing the blood-brain barrier. The most studied compounds included curcumin, quercetin, carbamazepine, diazepam, and insulin, each with therapeutic applications in neurodegenerative and psychiatric disorders. The findings highlight growing interest in intranasal nano- and microemulsions as a non-invasive and efficient CNS delivery strategy. Future research can bridge translational gaps, enhancing efficacy and safety while meeting regulatory expectations for patient-centered drug development. This study provides a comprehensive overview of current trends and serves as a guide for advancing innovative intranasal delivery platforms.
纳米乳剂和微乳剂是很有前景的药物递送系统，能够提高活性药物成分的溶解度、稳定性和生物利用度，尤其适用于中枢神经系统（CNS）疾病。本研究基于Scopus数据库的数据，对2004年至2024年关于鼻内纳米乳剂的科学出版物进行了文献计量分析。使用Bibliometrix和VOSviewer对总共379篇文章进行了分析，以确定出版趋势、主要国家和机构、著名期刊以及关键词网络。在过去十年中，出版物数量显著增长，印度、美国和中国的发文量领先。关键词分析揭示了与“脑靶向”“药物递送”和“鼻内给药”相关的强大主题集群，突出了这条途径绕过血脑屏障的潜力。研究最多的化合物包括姜黄素、槲皮素、卡马西平、地西泮和胰岛素，它们在神经退行性疾病和精神疾病中均有治疗应用。研究结果凸显了人们对鼻内纳米乳剂和微乳剂作为一种非侵入性且高效的中枢神经系统递送策略的兴趣日益浓厚。未来的研究可以弥合转化差距，提高疗效和安全性，同时满足以患者为中心的药物开发的监管期望。本研究全面概述了当前趋势，并为推进创新的鼻内递送平台提供了指导。
