He Qi, Yu Hong, Zhou Xinyao, Yang Kangyi, Xiao Wenjie, Gao Zirui, He Qian
Department of Human Anatomy, Institute of Basic Medicine, North Sichuan Medical College, Nanchong, China.
Midwifery Major, Nursing College, North Sichuan Medical College, Nanchong, China.
Front Neurosci. 2025 Sep 11;19:1593188. doi: 10.3389/fnins.2025.1593188. eCollection 2025.
The pathogenesis of Alzheimer's disease (AD) is closely linked to astrocytes. This study conducts a bibliometric analysis of data from a wide range of literature in this field to enhance the in-depth understanding of this area.
Publications were retrieved from the 2000-2025 Web of Science Core Collection on January 21, 2025. Bibliometrix-package of R, VOSviewer and CiteSpace were used to visualize the research focus and trends.
The number of citations for the top 100 articles ranged from 208 to 602 citations, with a median of 293 and an average of 331.67 citations per article. The author with the most contributions to this collection was Holtzman David M, who authored 7 papers. Most articles originated in the United States ( = 69), while Washington University was the institution with the most cited manuscripts ( = 40). The contributed the most publications ( = 15), followed by ( = 7). Co-occurrence of keywords analysis unveiled earlier studies focusing on "messenger RNA," and "IFN-," recent studies concentrated on "mechanisms," and "activation." Moreover, keywords burst analysis indicated that the most recent prominent keywords were "Aβ," "activation" and "association" since 2016.
This is the first bibliometric analysis of the top 100 cited research on astrocytes and AD from 2000 to 2025, underscoring that the United States is a prominent leader in this field. Our analysis highlighted the growing interest in the pathogenesis of astrocytes in AD. Future studies on the mechanisms underlying astrocytes in AD will facilitate further research on new therapeutic approaches.
阿尔茨海默病（AD）的发病机制与星形胶质细胞密切相关。本研究对该领域大量文献数据进行文献计量分析，以加深对该领域的深入理解。
于2025年1月21日从2000 - 2025年的科学网核心合集中检索出版物。使用R语言的Bibliometrix包、VOSviewer和CiteSpace对研究重点和趋势进行可视化。
前100篇文章的被引次数在208至602次之间，中位数为293次，平均每篇文章被引331.67次。对该合集贡献最大的作者是霍尔茨曼·大卫·M，他撰写了7篇论文。大多数文章起源于美国（n = 69），而华盛顿大学是被引手稿最多的机构（n = 40）。《细胞》贡献的出版物最多（n = 15），其次是《自然》（n = 7）。关键词共现分析显示，早期研究集中在“信使核糖核酸”和“干扰素”，近期研究集中在“机制”和“激活”。此外，关键词突现分析表明，自2016年以来最突出的关键词是“淀粉样β蛋白”、“激活”和“关联”。
这是对2000年至2025年关于星形胶质细胞与AD的被引次数排名前100的研究的首次文献计量分析，强调美国是该领域的突出领导者。我们的分析突出了对AD中星形胶质细胞发病机制的兴趣日益增加。未来对AD中星形胶质细胞潜在机制的研究将有助于进一步开展新治疗方法的研究。
