An Xiaoqiong, He Jun, Bi Bin, Wu Gang, Xu Jianwei, Yu Wenfeng, Ren Zhenkui
Department of Laboratory Medicine, The Second People's Hospital of Guizhou Province, Guiyang, China.
Key Laboratory of Molecular Biology, Guizhou Medical University, Guiyang, Guizhou, China.
Front Aging Neurosci. 2024 Nov 27;16:1481748. doi: 10.3389/fnagi.2024.1481748. eCollection 2024.
Alzheimer's disease (AD) is a neurodegenerative disorder marked by cognitive decline and memory loss. Recent research underscores the crucial role of astrocytes in AD. This study reviews research trends and contributions on astrocytes in AD from 2000 to 2024, shedding light on the evolving research landscape.
We conducted a bibliometric analysis using data from the Web of Science Core Collection, covering publications from January 1, 2000, to July 6, 2024, on "Alzheimer's disease" and "astrocytes." We identified 5,252 relevant English articles and reviews. For data visualization and analysis, we used VOSviewer, CiteSpace, and the R package "bibliometrix," examining collaboration networks, co-citation networks, keyword co-occurrence, and thematic evolution.
Between 2000 and 2024, 5,252 publications were identified, including 4,125 original research articles and 1,127 review articles. Publications increased significantly after 2016. The United States had the most contributions (1,468), followed by China (836). Major institutions were the University of California system (517) and Harvard University (402). The Journal of Alzheimer's Disease published the most articles (215). Verkhratsky A was the top author with 51 papers and 1,585 co-citations.
Our extensive bibliometric analysis indicates a significant increase in research on astrocytes in AD over the past 20 years. This study emphasizes the growing acknowledgment of astrocytes' crucial role in AD pathogenesis and points to future research on their mechanisms and therapeutic potential.
阿尔茨海默病（AD）是一种以认知衰退和记忆丧失为特征的神经退行性疾病。近期研究强调了星形胶质细胞在AD中的关键作用。本研究回顾了2000年至2024年关于AD中星形胶质细胞的研究趋势和贡献，揭示了不断演变的研究格局。
我们使用科学网核心合集的数据进行文献计量分析，涵盖2000年1月1日至2024年7月6日发表的关于“阿尔茨海默病”和“星形胶质细胞”的文献。我们确定了5252篇相关的英文文章和综述。为了进行数据可视化和分析，我们使用了VOSviewer、CiteSpace和R包“bibliometrix”，研究合作网络、共被引网络、关键词共现和主题演变。
2000年至2024年期间，共确定了5252篇出版物，其中包括4125篇原创研究文章和1127篇综述文章。2016年后出版物数量显著增加。美国的贡献最大（1468篇），其次是中国（836篇）。主要机构是加利福尼亚大学系统（517篇）和哈佛大学（402篇）。《阿尔茨海默病杂志》发表的文章最多（215篇）。Verkhratsky A是发表论文最多的作者，有51篇论文和1585次共被引。
我们广泛的文献计量分析表明，在过去20年中，关于AD中星形胶质细胞的研究显著增加。本研究强调了对星形胶质细胞在AD发病机制中关键作用的认识不断提高，并指出了未来关于其机制和治疗潜力的研究方向。
