Chow Amy, Laklouk Israa
Endocrinology, University of California Los Angeles David Geffen School of Medicine, Thousand Oaks, USA.
Pathology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Cureus. 2025 Aug 28;17(8):e91182. doi: 10.7759/cureus.91182. eCollection 2025 Aug.
Warthin-like variant of papillary thyroid cancer (WLPTC) is a rare subtype of papillary thyroid cancer (PTC). Its symptoms, diagnosis, treatment, and prognosis are comparable to those of the classic type of PTC. However, certain aggressive PTC variants may mimic WLPTC, making accurate diagnosis essential since management and follow-up can differ. Here, we report a case of a 64-year-old man who was diagnosed with WLPTC. He initially presented to the hospital with worsening blurry vision of the right eye over a few days. During evaluation, an incidental right neck mass was detected, and fine-needle aspiration was performed. The pathology revealed thyroid carcinoma. The patient subsequently underwent total thyroidectomy with modified neck dissection, and histological analysis identified WLPTC. Postoperatively, he received radioactive iodine therapy and thyroid hormone therapy. His follow-up visits showed a favorable outcome two years later. This case highlights the importance of identifying WLPTC, as accurate diagnosis is crucial for ensuring appropriate clinical management and follow-up for patients.
甲状腺乳头状癌的沃辛样变异型（WLPTC）是甲状腺乳头状癌（PTC）的一种罕见亚型。其症状、诊断、治疗和预后与经典型PTC相似。然而，某些侵袭性PTC变异型可能酷似WLPTC，鉴于管理和随访可能不同，准确诊断至关重要。在此，我们报告一例64岁男性被诊断为WLPTC的病例。他最初因右眼视力在数天内逐渐恶化而就诊于医院。在评估过程中，偶然发现右侧颈部肿块，并进行了细针穿刺抽吸。病理显示为甲状腺癌。患者随后接受了全甲状腺切除术及改良颈部淋巴结清扫术，组织学分析确诊为WLPTC。术后，他接受了放射性碘治疗和甲状腺激素治疗。两年后的随访显示预后良好。该病例凸显了识别WLPTC的重要性，因为准确诊断对于确保患者得到适当的临床管理和随访至关重要。
