兔抗链球菌碳水化合物抗体个体抗原特异性的遗传
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates.
作者信息
Eichmann K, Kindt T J
出版信息
J Exp Med. 1971 Aug 1;134(2):532-52. doi: 10.1084/jem.134.2.532.
The inheritance of individual antigenic specificities (IAS) of rabbit antibodies to the Group C streptococcal carbohydrate was demonstrated in a selectively bred rabbit family. The IAS of the antibodies from 3 proband rabbits were also observed in the Group C antibodies in as many as 7 out of 42 related rabbits, but in none of the Group C antibodies from 48 unrelated rabbits, Immunodiffusion analyses and quantitative radioprecipitin experiments revealed that this cross-specificity may be either partial or complete. Quantitative inhibition of the precipitin reaction between the proband antibody and its antiserum by preimmune IgG revealed 30-fold differences in the proportion of molecules with cross-specificity for the proband antibody. This proportion is higher in the preimmune IgG of the proband rabbit and of those relatives which produced cross-precipitating antibodies than it is in the IgG of rabbits which had the same group a allotype, but did not produce cross-precipitating antibodies. The proportion is much lower in the IgG of rabbits with a group a allotype different from that of the proband antibody. These data suggest that serologically detected individual antigenic specificities are inherited markers of immunoglobulins.
在一个经过选择性培育的兔家族中，证实了兔抗C群链球菌碳水化合物抗体的个体抗原特异性（IAS）的遗传情况。在42只相关兔中，多达7只兔的C群抗体中也观察到了来自3只先证者兔抗体的IAS，但在48只无关兔的C群抗体中均未观察到。免疫扩散分析和定量放射沉淀实验表明，这种交叉特异性可能是部分的或完全的。用免疫前IgG对先证者抗体与其抗血清之间的沉淀反应进行定量抑制，结果显示，对先证者抗体具有交叉特异性的分子比例存在30倍的差异。在先证者兔及其产生交叉沉淀抗体的亲属的免疫前IgG中，这一比例高于具有相同a组同种异型但未产生交叉沉淀抗体的兔的IgG中的比例。在与先证者抗体a组同种异型不同的兔的IgG中，这一比例要低得多。这些数据表明，血清学检测到的个体抗原特异性是免疫球蛋白的遗传标记。
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