同源兔抗体重链上A组同种异型特异性的多样表达
Diverse expression of group a allotype specificities on the heavy chains of homogeneous rabbit antibodies.
作者信息
Kindt T J, Seide R K, Tack B F, Todd C W
出版信息
J Exp Med. 1973 Jul 1;138(1):33-43. doi: 10.1084/jem.138.1.33.
Abstract
Variations in the ability of homogeneous antibodies to absorb group a allotype antisera suggest that these V(H) region allotypes comprise a spectrum of specificities. While no homogeneous antibody tested would completely absorb antisera to the group a specificities, the total IgG preparations from individual rabbits was capable of doing so, including preimmune IgG from the rabbits that produced the homogeneous antibodies. Differences in the serologic reactivities of homogeneous antibodies indicate that each possesses only a portion of the spectrum of the allotypic specificities expressed by the total IgG.
摘要
同源抗体吸收A组同种异型抗血清能力的差异表明，这些V(H)区域同种异型包含一系列特异性。虽然所测试的同源抗体均不能完全吸收针对A组特异性的抗血清，但来自个体兔子的总IgG制剂能够做到这一点，包括产生同源抗体的兔子的免疫前IgG。同源抗体血清学反应性的差异表明，每种同源抗体仅拥有总IgG所表达的同种异型特异性谱的一部分。
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