• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Diverse expression of group a allotype specificities on the heavy chains of homogeneous rabbit antibodies.同源兔抗体重链上A组同种异型特异性的多样表达
J Exp Med. 1973 Jul 1;138(1):33-43. doi: 10.1084/jem.138.1.33.
2
Serologic identity of the b4 allotypic determinants present on homogeneous rabbit light chains with different N-terminal amino acid sequences.
J Immunol. 1972 Oct;109(4):735-41.
3
An idiotypic cross-reaction between allotype a3 and allotype a negative rabbit antibodies to streptococcal carbohydrate.同种异型a3与抗链球菌碳水化合物的同种异型阴性兔抗体之间的独特型交叉反应。
J Exp Med. 1973 Mar 1;137(3):636-48. doi: 10.1084/jem.137.3.636.
4
Rabbit latent group a allotypes: characterization and relationship to nominal group a allotypic specificities.兔潜在的A组同种异型:特征及其与标称A组同种异型特异性的关系。
J Immunol. 1978 Sep;121(3):1132-8.
5
The structural basis of rabbit VH allotypes: serologic studies on a1 H chains with defined amino acid sequence.兔VH同种异型的结构基础:对具有明确氨基酸序列的α1重链的血清学研究。
J Immunol. 1977 Jul;119(1):287-94.
6
Amino acid sequence of the N-terminal sixty-nine residues of heavy chain derived from a homogeneous rabbit antibody.源自一种纯合兔抗体的重链N端69个残基的氨基酸序列。
Biochem J. 1972 Nov;130(2):539-46. doi: 10.1042/bj1300539.
7
The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates.兔抗链球菌碳水化合物抗体个体抗原特异性的遗传
J Exp Med. 1971 Aug 1;134(2):532-52. doi: 10.1084/jem.134.2.532.
8
Restricted rabbit antibodies: amino acid sequences of rabbit H chains of allotype a1, a2, and a3 in the region 80 to 94.受限兔抗体:同种异型a1、a2和a3的兔重链在80至94区域的氨基酸序列。
J Immunol. 1973 Dec;111(6):1838-43.
9
Studies of hyperimmune restricted and partially restricted anti-pneumococcal polysaccharide antibodies from allotype-defined pedigreed rabbits. II. Allotypes and idiotypes in sera and electrofocused fractions.对来自同种异型定义的纯种兔的超免疫受限和部分受限抗肺炎球菌多糖抗体的研究。II. 血清和电聚焦组分中的同种异型和独特型
Eur J Immunol. 1974 Aug;4(8):560-4. doi: 10.1002/eji.1830040808.
10
Human immunoglobulins with a1 allotypic determinants of rabbit immunoglobulin heavy chains.具有兔免疫球蛋白重链a1同种异型决定簇的人免疫球蛋白。
Nature. 1975 Jan 17;253(5488):216-7. doi: 10.1038/253216a0.

引用本文的文献

1
Partial amino acid sequence in the N-terminal region of an anti-pneumococcal immunoglobulin heavy chain of allotype alpha2.同种异型α2抗肺炎球菌免疫球蛋白重链N端区域的部分氨基酸序列
Biochem J. 1974 Apr;139(1):281-3. doi: 10.1042/bj1390281.
2
A genetic marker in the variable region of rabbit immunoglobulin heavy chain.兔免疫球蛋白重链可变区中的一个遗传标记。
Biochem J. 1975 Nov;151(2):351-9. doi: 10.1042/bj1510351.
3
Isolation and characterization of IgG molecules expressing latent group b allotypes from pedigreed b4b4 rabbits.从纯种b4b4兔中分离并鉴定表达潜在B组同种异型的IgG分子。
J Exp Med. 1978 Aug 1;148(2):522-33. doi: 10.1084/jem.148.2.522.

本文引用的文献

1
Allotype-related sequence variation of the heavy chain of rabbit immunoglobulin G.兔免疫球蛋白 G 重链同种异型相关序列变异。
Biochem J. 1968 May;107(6):753-63. doi: 10.1042/bj1070753.
2
Allotypy of rabbit serum proteins. I. Immuno-chemical analysis leading to the individualization of seven main allotypes.兔血清蛋白的同种异型。I. 免疫化学分析确定七种主要同种异型的个体差异
J Exp Med. 1960 Jul 1;112(1):107-24. doi: 10.1084/jem.112.1.107.
3
Expression of allelic and non-allelic genes in immunoglobulin light chains from homozygous rabbits.纯合兔免疫球蛋白轻链中等位基因和非等位基因的表达。
FEBS Lett. 1970 Dec 18;11(5):339-341. doi: 10.1016/0014-5793(70)80563-4.
4
Variations at the carboxyl-terminal amino acid sequence of rabbit light chains with b4, b5 and b6 allotypic specificities.具有b4、b5和b6同种异型特异性的兔轻链羧基末端氨基酸序列的变异。
J Mol Biol. 1969 May 14;41(3):473-7. doi: 10.1016/0022-2836(69)90289-7.
5
A simplification of the radioactive antigen-binding test by a double label technique.采用双标记技术对放射免疫结合试验的简化。
J Immunol. 1971 Sep;107(3):910-1.
6
Allotype exclusion in uniform rabbit antibody to streptococcal carbohydrate.抗链球菌碳水化合物的兔单克隆抗体中的同种型排斥
J Exp Med. 1970 Feb;131(2):343-54. doi: 10.1084/jem.131.2.343.
7
Allotypically related sequences in the Fd fragment of rabbit immunoglobulin heavy chains.兔免疫球蛋白重链Fd片段中的同种异型相关序列。
Biochem J. 1971 Sep;124(2):301-18. doi: 10.1042/bj1240301.
8
Relationships between relative binding affinity and electrophoretic behavior of rabbit antibodies to streptococcal carbohydrates.兔抗链球菌碳水化合物抗体的相对结合亲和力与电泳行为之间的关系。
J Exp Med. 1971 Mar 1;133(3):424-41. doi: 10.1084/jem.133.3.424.
9
Variation in the N-terminal sequence of heavy chains of immunoglobulin G from rabbits of different allotype.不同同种异型兔免疫球蛋白G重链N端序列的变异
Biochem J. 1969 Apr;112(2):173-85. doi: 10.1042/bj1120173.
10
Rabbit immunoglobulin light chains: correlation of variable region sequences with allotypic markers.兔免疫球蛋白轻链:可变区序列与同种异型标记的相关性。
J Immunol. 1973 Jan;110(1):227-32.

同源兔抗体重链上A组同种异型特异性的多样表达

Diverse expression of group a allotype specificities on the heavy chains of homogeneous rabbit antibodies.

作者信息

Kindt T J, Seide R K, Tack B F, Todd C W

出版信息

J Exp Med. 1973 Jul 1;138(1):33-43. doi: 10.1084/jem.138.1.33.

DOI:10.1084/jem.138.1.33
PMID:4123829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2180544/
Abstract

Variations in the ability of homogeneous antibodies to absorb group a allotype antisera suggest that these V(H) region allotypes comprise a spectrum of specificities. While no homogeneous antibody tested would completely absorb antisera to the group a specificities, the total IgG preparations from individual rabbits was capable of doing so, including preimmune IgG from the rabbits that produced the homogeneous antibodies. Differences in the serologic reactivities of homogeneous antibodies indicate that each possesses only a portion of the spectrum of the allotypic specificities expressed by the total IgG.

摘要

同源抗体吸收A组同种异型抗血清能力的差异表明,这些V(H)区域同种异型包含一系列特异性。虽然所测试的同源抗体均不能完全吸收针对A组特异性的抗血清,但来自个体兔子的总IgG制剂能够做到这一点,包括产生同源抗体的兔子的免疫前IgG。同源抗体血清学反应性的差异表明,每种同源抗体仅拥有总IgG所表达的同种异型特异性谱的一部分。