同种异型a3与抗链球菌碳水化合物的同种异型阴性兔抗体之间的独特型交叉反应。
An idiotypic cross-reaction between allotype a3 and allotype a negative rabbit antibodies to streptococcal carbohydrate.
作者信息
Kindt T J, Klapper D G, Waterfield M D
出版信息
J Exp Med. 1973 Mar 1;137(3):636-48. doi: 10.1084/jem.137.3.636.
Abstract
Two antibodies to Group C streptococcal carbohydrate isolated from an individual rabbit had similar relative binding affinities for a Group C immuno-adsorbent column. Their light chains were similar, if not identical, as were the constant regions of their heavy chains. Differences in the variable regions of the H chains of the two antibodies were detected by chemical analysis. The two antibodies had serologically identical idiotypic determinants although one antibody possessed the a3 allotype and the other had no detectable group a marker. The occurrence of such antibodies indicates the absence of obligatory associations between group a allotypes and idiotypic specificities, despite the fact that both determinants have antigenic components in the V(H) region of the H chain.
摘要
从一只兔子体内分离出的两种抗C群链球菌碳水化合物抗体，对C群免疫吸附柱具有相似的相对结合亲和力。它们的轻链相似，即便不完全相同，重链的恒定区也是如此。通过化学分析检测到这两种抗体重链可变区存在差异。这两种抗体具有血清学上相同的独特型决定簇，尽管一种抗体具有a3同种异型，而另一种没有可检测到的a组标记。此类抗体的出现表明，尽管a组同种异型和独特型特异性的决定簇在重链的V(H)区域都具有抗原成分，但它们之间不存在必然联系。
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