抗原结合性胸腺衍生淋巴细胞。II. 免疫球蛋白决定簇的性质。
Antigen-binding thymus-derived lymphocytes. II. Nature of the immunoglobulin determinants.
作者信息
Hogg N M, Greaves M F
出版信息
Immunology. 1972 Jun;22(6):967-80.
Abstract
Thymus-derived rosette'-forming lymphocytes which have been separated from other SRBC-sensitive cells by means of cotton wool columns were examined for the presence of immunoglobulin. This was carried out by inhibition of rosette formation by anti-immunoglobulin sera. Inhibition was effected by a number of anti-IgM sera shown to contain antibodies with specificities directed towards the hinge' region of the μ chain. No other heavy chain specific antisera were inhibitory. The ratio of rosette inhibition by anti-κ and anti-λ light chain sera varied during the course of the response to SRBC, the latter inhibiting by 89 per cent 3 days post-immunization.
摘要
通过棉纤维柱从其他对绵羊红细胞敏感的细胞中分离出来的胸腺来源的“玫瑰花结”形成淋巴细胞，检测其免疫球蛋白的存在情况。这是通过抗免疫球蛋白血清对玫瑰花结形成的抑制来进行的。抑制作用由多种抗IgM血清实现，这些血清显示含有针对μ链“铰链”区的特异性抗体。没有其他重链特异性抗血清具有抑制作用。在对绵羊红细胞的反应过程中，抗κ和抗λ轻链血清的玫瑰花结抑制率有所不同，后者在免疫后3天的抑制率为89%。
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Antigen-binding thymus-derived lymphocytes. II. Nature of the immunoglobulin determinants.抗原结合性胸腺衍生淋巴细胞。II. 免疫球蛋白决定簇的性质。
Immunology. 1972 Jun;22(6):967-80.
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本文引用的文献
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The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
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[IMMUNO-CYTO-ADHESION: A SIMPLE AND QUANTITATIVE METHOD FOR THE STUDY IN VITRO OF ANTIBODY-PRODUCING CELLS].[免疫细胞黏附：一种用于体外研究抗体产生细胞的简单定量方法]
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Human serum macroglobulins and dissociation units. I. Physicochemical properties.人血清巨球蛋白与解离单位。I. 物理化学性质。
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Chemical coupling of proteins to agarose.蛋白质与琼脂糖的化学偶联。
Nature. 1967 Sep 30;215(5109):1491-2. doi: 10.1038/2151491a0.
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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳测定分子量的可靠性。
J Biol Chem. 1969 Aug 25;244(16):4406-12.
6
7
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
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