铜绿假单胞菌中β-内酰胺类抗生素耐药性相关因素。
Factors involved in beta-lactam antibiotic resistance in Pseudomonas aeruginosa.
作者信息
Ohmori H, Azuma A, Suzuki Y, Hashimoto Y
出版信息
Antimicrob Agents Chemother. 1977 Oct;12(4):537-9. doi: 10.1128/AAC.12.4.537.
Abstract
A temperature-sensitive mutant, strain SS, which is assumed to be devoid of beta-lactamase activity and deficient in a permeability barrier to antibiotics, was isolated from a beta-lactamase-less mutant, strain L-2, derived from Pseudomonas aeruginosa IFO 3080. By comparing the beta-lactam antibiotic susceptibility between strains IFO 3080, L-2, and SS, the involvement of both beta-lactamase and a permeability barrier in determining the beta-lactam antibiotic resistance was estimated.
摘要
从源自铜绿假单胞菌IFO 3080的无β-内酰胺酶突变株L-2中分离出一种温度敏感突变株SS，该突变株被认为缺乏β-内酰胺酶活性且对抗生素的通透性屏障存在缺陷。通过比较IFO 3080、L-2和SS菌株对β-内酰胺抗生素的敏感性，评估了β-内酰胺酶和通透性屏障在决定β-内酰胺抗生素抗性中的作用。
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