小鼠中H-2类型与对IgG（γ2a）同种异型免疫反应性的遗传控制的关联。
Association of H-2 types with genetic control of immune reponsiveness to IgG (gamma2a) allotypes in the mouse.
作者信息
Lieberman R, Humphrey W
出版信息
J Exp Med. 1972 Nov 1;136(5):1222-30. doi: 10.1084/jem.136.5.1222.
Abstract
Immune responsiveness to IgG allotypes in the mouse was found to be controlled by an immune response gene Ir-IgG linked to the H-2 locus. This was demonstrated by the analysis of the immune response to BALB/c IgG (gamma2a) myeloma proteins in mice of various H-2 types from five different linkage groups of immunoglobulin heavy chains. Antisera were examined for antibodies to idiotypic (Fab) and allotypic (Fc) specificities. No immune response to BALB/c IgG myeloma proteins was found in mice with the same heavy-chain immunoglobulin linkage group as BALB/c but of different H-2 types. In mice with immunoglobulin heavy chains that are different than BALB/c, a high immune response to IgG myeloma proteins was found in H-2 types b, bc, p, r, s, and v; a low response in a, d, k, and q. The Ir-IgG gene is controlled by a dominant autosomal gene.
摘要
研究发现，小鼠对IgG同种异型的免疫反应性受与H-2基因座连锁的免疫反应基因Ir-IgG控制。这是通过对来自免疫球蛋白重链五个不同连锁群的各种H-2类型小鼠对BALB/c IgG（γ2a）骨髓瘤蛋白的免疫反应进行分析得以证明的。检测抗血清中针对独特型（Fab）和同种异型（Fc）特异性的抗体。与BALB/c具有相同重链免疫球蛋白连锁群但H-2类型不同的小鼠，未发现对BALB/c IgG骨髓瘤蛋白的免疫反应。在免疫球蛋白重链与BALB/c不同的小鼠中，发现H-2类型b、bc、p、r、s和v对IgG骨髓瘤蛋白有高免疫反应；a、d、k和q类型反应较低。Ir-IgG基因受一个显性常染色体基因控制。
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