小鼠中由Ir区域控制的抗原的血清学证据。
Serologic evidence for antigens controlled by the Ir region in mice.
作者信息
Götze D, Reisfeld R A, Klein J
出版信息
J Exp Med. 1973 Oct 1;138(4):1003-8. doi: 10.1084/jem.138.4.1003.
Abstract
Antibodies produced in B10.D2 mice against soluble lymphocyte membrane antigens of B10.A (H-2(a)) mice reacted only with lymphocytes of the strains carrying the Ir(k) region, i.e., B10.A(2R), B10.K, B10.BR, B10.HTT, AQR, A.TE, C3H, and CBA; they did not react with cells of strains carrying different Ir regions, i.e., B10.A(4R), B10, B10.M, A.SW, DBA/1. It is therefore concluded that the antigen detected with these antibodies is apparently controlled by the Ir region of the H-2 complex. The antigen is present on some T lymphocytes and absent on B lymphocytes. Its presence or absence seems to correlate with MLC and GVH reactivity.
摘要
B10.D2小鼠产生的针对B10.A（H-2(a)）小鼠可溶性淋巴细胞膜抗原的抗体，仅与携带Ir(k)区域的品系的淋巴细胞发生反应，即B10.A(2R)、B10.K、B10.BR、B10.HTT、AQR、A.TE、C3H和CBA；它们不与携带不同Ir区域的品系的细胞发生反应，即B10.A(4R)、B10、B10.M、A.SW、DBA/1。因此得出结论，用这些抗体检测到的抗原显然受H-2复合体的Ir区域控制。该抗原存在于一些T淋巴细胞上，而不存在于B淋巴细胞上。其存在与否似乎与混合淋巴细胞培养和移植物抗宿主反应性相关。
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The H-2 system: past and present.H-2系统：过去与现在
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Serological identification of an Ir-region product.Ir区域产物的血清学鉴定。
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