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鼠肉瘤病毒温度敏感突变体的分离

Isolation of temperature-sensitive mutants of murine sarcoma virus.

作者信息

Scolnick E M, Stephenson J R, Aaronson S A

出版信息

J Virol. 1972 Oct;10(4):653-7. doi: 10.1128/JVI.10.4.653-657.1972.

DOI:10.1128/JVI.10.4.653-657.1972
PMID:4117345
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356516/
Abstract

Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.

摘要

已分离出三种不同的鼠肉瘤病毒非生产性细胞系，它们在维持转化方面对温度敏感。在每种情况下，温度敏感效应的原因是病毒而非细胞基因突变。用鼠白血病病毒对其中一个突变体进行超感染可克服转化状态下的温度敏感变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7c/356516/80cc81f261cb/jvirol00274-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7c/356516/80cc81f261cb/jvirol00274-0101-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f7c/356516/80cc81f261cb/jvirol00274-0101-a.jpg

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Isolation of temperature-sensitive mutants of murine sarcoma virus.鼠肉瘤病毒温度敏感突变体的分离
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本文引用的文献

1
Viral etiology of spontaneous mouse leukemia; a review.自发性小鼠白血病的病毒病因学；综述
Cancer Res. 1958 May;18(4):371-81.
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Virus specific RNA in cells transformed by RNA tumour viruses.RNA肿瘤病毒转化细胞中的病毒特异性RNA
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Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses.从非感染性仓鼠肿瘤中拯救莫洛尼肉瘤病毒的缺陷基因组，并利用各种鼠白血病病毒生产假型肉瘤病毒。
骨髓增殖性肉瘤病毒温度敏感突变体的作用表明，成纤维细胞转化病毒特性和造血转化病毒特性是相关的。
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Toward a model for the molecular genetics of carcinogenesis in rats.建立大鼠致癌作用分子遗传学模型。
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Selection of revertants of Kirsten sarcoma virus transformed nonproducer BALB-3T3 cells.Kirsten肉瘤病毒转化的非生产性BALB-3T3细胞回复突变体的选择。
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Demonstration of a cell-surface antigen associated with murine sarcoma virus by immunoelectron microscopy.通过免疫电子显微镜对与鼠肉瘤病毒相关的细胞表面抗原的展示。
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7
Characterization of morphologic revertants of murine and avian sarcoma virus-transformed cells.鼠源和禽源肉瘤病毒转化细胞的形态学回复突变体的特性分析。
J Virol. 1973 Feb;11(2):218-22. doi: 10.1128/JVI.11.2.218-222.1973.
8
Expression of the major internal viral polypeptide in cells transformed by wild-type and temperature-sensitive murine sarcoma virus.野生型和温度敏感型鼠肉瘤病毒转化的细胞中主要病毒内部多肽的表达
J Virol. 1974 Nov;14(5):1245-52. doi: 10.1128/JVI.14.5.1245-1252.1974.
9
Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus.柯尔斯滕肉瘤病毒核酸序列的研究：一种含RNA的哺乳动物肉瘤病毒形成的模型。
J Virol. 1973 Sep;12(3):458-63. doi: 10.1128/JVI.12.3.458-463.1973.
10
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J Virol. 1987 Mar;61(3):889-97. doi: 10.1128/JVI.61.3.889-897.1987.
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1164-9. doi: 10.1073/pnas.56.4.1164.
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Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles.缺陷型莫洛尼肉瘤病毒颗粒在组织培养中产生改变的细胞病灶。
Proc Natl Acad Sci U S A. 1966 Apr;55(4):780-6. doi: 10.1073/pnas.55.4.780.
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Genetic stability of the sarcoma viruses in murine and avian sarcoma virus-transformed nonproducer cells.肉瘤病毒在鼠类和禽类肉瘤病毒转化的非生产性细胞中的遗传稳定性。
Int J Cancer. 1972 May 15;9(3):577-83. doi: 10.1002/ijc.2910090314.
6
Isolation of temperature-sensitive mutants of murine leukemia virus.鼠白血病病毒温度敏感突变体的分离。
Virology. 1972 Jun;48(3):749-56. doi: 10.1016/0042-6822(72)90158-4.
7
Plaque assay for some strains of avian leukosis virus.某些禽白血病病毒毒株的噬斑测定
Virology. 1972 Apr;48(1):126-35. doi: 10.1016/0042-6822(72)90120-1.
8
Characteristics of a conditional mutant of Rous sarcoma virus defective in ability to transform cells at high temperature.一种在高温下转化细胞能力有缺陷的劳斯肉瘤病毒条件突变体的特征。
Virology. 1972 Feb;47(2):444-55. doi: 10.1016/0042-6822(72)90280-2.
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Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells.鼠肉瘤病毒（柯斯顿）对小鼠和人类细胞转化的特性研究。
J Gen Virol. 1971 Nov;13(2):245-52. doi: 10.1099/0022-1317-13-2-245.
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Conditional lethal mutants of avian sarcoma viruses. II. Analysis of the temperature-sensitive lesion in ts 75.禽肉瘤病毒的条件致死突变体。II. ts 75中温度敏感损伤的分析。
Virology. 1971 Dec;46(3):745-53. doi: 10.1016/0042-6822(71)90076-6.