鼠肉瘤病毒温度敏感突变体的分离
Isolation of temperature-sensitive mutants of murine sarcoma virus.
作者信息
Scolnick E M, Stephenson J R, Aaronson S A
出版信息
J Virol. 1972 Oct;10(4):653-7. doi: 10.1128/JVI.10.4.653-657.1972.
Abstract
Three separate murine sarcoma virus nonproducer cell lines have been isolated which are temperature sensitive for the maintenance of transformation. In each case, a viral rather than a cellular genetic mutation is the reason for the temperature-sensitive effect. Superinfection of one of the mutants with murine leukemia virus overcomes the temperature-sensitive change in the transformed state.
摘要
已分离出三种不同的鼠肉瘤病毒非生产性细胞系，它们在维持转化方面对温度敏感。在每种情况下，温度敏感效应的原因是病毒而非细胞基因突变。用鼠白血病病毒对其中一个突变体进行超感染可克服转化状态下的温度敏感变化。
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