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在巨细胞病毒感染的细胞中产生的具有病毒抗原性的非病毒微体。

Nonviral microbodies with viral antigenicity produced in cytomegalovirus-infected cells.

作者信息

Craighead J E, Kanich R E, Almeida J D

出版信息

J Virol. 1972 Oct;10(4):766-75. doi: 10.1128/JVI.10.4.766-775.1972.

DOI:10.1128/JVI.10.4.766-775.1972
PMID:4117347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC356532/
Abstract

Masses of homogeneous electron-dense material accumulate in the cytoplasmic inclusions of cultured fibroblasts which have been infected with "wild" and "adapted" strains of human cytomegalovirus. The substance appears to be produced by microtubular membranes and the Golgi apparatus; ultrastructural histochemistry suggests that it is not lysosomal in nature nor is it comprised of lipids or polysaccharides. The dense material "buds" into cytoplasmic tubules forming circumscribed bodies having an investing membrane similar to the viral envelope. After transport to the extracellular milieu in cytoplasmic tubules and vesicles, virions and dense bodies can be demonstrated by immune electron microscopy. The homogeneous dense body appears to be a unique product of the cytomegalovirus-infected cell which possesses a limiting membrane having antigenic determinants common with the viral envelope.

摘要

在感染了人类巨细胞病毒“野生”株和“适应”株的培养成纤维细胞的胞质内含物中，积累了大量均匀的电子致密物质。该物质似乎由微管膜和高尔基体产生；超微结构组织化学表明，它本质上不是溶酶体，也不是由脂质或多糖组成。致密物质“芽生”到胞质小管中，形成具有类似于病毒包膜的包被膜的界限分明的小体。在通过胞质小管和囊泡运输到细胞外环境后，病毒粒子和致密小体可通过免疫电子显微镜检测到。均匀的致密小体似乎是巨细胞病毒感染细胞的独特产物，其具有与病毒包膜共有的抗原决定簇的界限膜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/3f74e246a4d8/jvirol00274-0220-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/4bd272c9ff4c/jvirol00274-0219-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/3f74e246a4d8/jvirol00274-0220-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/55594508c93e/jvirol00274-0213-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/e5d22661041e/jvirol00274-0214-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/d56edecfad73/jvirol00274-0215-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/db61d60f7580/jvirol00274-0215-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/328983bb4425/jvirol00274-0216-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/078964a0a3df/jvirol00274-0216-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/8c9ca6f21d09/jvirol00274-0216-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/04ba819f55ff/jvirol00274-0216-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/8085187b2f41/jvirol00274-0216-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/eab85e0c4217/jvirol00274-0217-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/e64c8c27c8d4/jvirol00274-0217-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/4a9d709d6c7c/jvirol00274-0217-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/e3250e895c21/jvirol00274-0218-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/091be2a029a9/jvirol00274-0218-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fde9/356532/6f7b187f73cf/jvirol00274-0218-c.jpg
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