紫外线照射的枯草芽孢杆菌recA中脱氧核糖核酸的修复及随后的断裂
Repair and subsequent fragmentation of deoxyribonucleic acid in ultraviolet-irradiated Bacillus subtilis recA.
作者信息
Hadden C T
出版信息
J Bacteriol. 1977 Dec;132(3):856-61. doi: 10.1128/jb.132.3.856-861.1977.
Abstract
Cells of Bacillus subtilis recA1 are sensitive to irradiation with ultraviolet light. Evidence is presented here that these cells are not defective in ultraviolet light-induced incision of deoxyribonucleic acid (DNA) or repair DNA synthesis. Ligation of DNA at repair sites appears to occur, but the DNA is subsequently fragmented, apparently at sites of previous repair synthesis. It is hypothesized that the defect in DNA repair leads to host-specific restriction at repaired sites because of a defect in either the structure of the repaired region or specificity of the restriction/modification system.
摘要
枯草芽孢杆菌recA1的细胞对紫外线照射敏感。本文提供的证据表明，这些细胞在紫外线诱导的脱氧核糖核酸（DNA）切口或修复性DNA合成方面没有缺陷。修复位点处的DNA连接似乎会发生，但随后DNA会碎片化，显然是在先前修复合成的位点。据推测，DNA修复缺陷会导致修复位点处的宿主特异性限制，这是由于修复区域的结构缺陷或限制/修饰系统的特异性缺陷所致。
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