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1
6-(p-hydroxyphenylazo)-uracil: a selective inhibitor of host DNA replication in phage-infected Bacillus subtilis.6-（对羟基苯偶氮）尿嘧啶：噬菌体感染的枯草芽孢杆菌中宿主DNA复制的选择性抑制剂。
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1454-61. doi: 10.1073/pnas.67.3.1454.
2
Resistance of bacteriophage PBS2 infection to 6-(p-hydroxyphenylazo)-uracil, an inhibitor of Bacillus subtilis deoxyribonucleic acid synthesis.噬菌体PBS2感染对6-（对羟基苯偶氮）尿嘧啶（一种枯草芽孢杆菌脱氧核糖核酸合成抑制剂）的抗性。
J Virol. 1973 Feb;11(2):338-40. doi: 10.1128/JVI.11.2.338-340.1973.
3
Selective replication of bacteriophage phi29 deoxyribonucleic acid in 6-(p-hydroxyphenylazo)-uracil-treated Bacillus subtilis.噬菌体phi29脱氧核糖核酸在6-（对羟基苯偶氮）-尿嘧啶处理的枯草芽孢杆菌中的选择性复制。
J Virol. 1973 Jan;11(1):153-5. doi: 10.1128/JVI.11.1.153-155.1973.
4
Inhibition of bacterial DNA replication in vitro by 6-(p-hydroxyphenylazo)-uracil: selective interference with the function of deoxyguanosine nucleotides.6-（对羟基苯偶氮）尿嘧啶在体外对细菌DNA复制的抑制作用：对脱氧鸟苷核苷酸功能的选择性干扰。
Biochim Biophys Acta. 1972 Oct 11;281(2):202-15.
5
Induction of prophage SPO2 in Bacillus subtilis by 6-(para)-hydroxyphenylazouracil.6-（对）-羟基苯基偶氮尿嘧啶诱导枯草芽孢杆菌中的原噬菌体SPO2
J Virol. 1974 Dec;14(6):1470-5. doi: 10.1128/JVI.14.6.1470-1475.1974.
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A comparison of the utilization of thymine and thymidine as precursors for deoxyribonucleic acid synthesis in Bacillus subtilis, and their specific inhibition by 6-(p-hydroxyphenylazo)uracil and caffeine.枯草芽孢杆菌中胸腺嘧啶和胸腺嘧啶核苷作为脱氧核糖核酸合成前体的利用情况比较，以及它们被6-（对羟基苯偶氮）尿嘧啶和咖啡因特异性抑制的情况。
Biochem J. 1972 Sep;129(3):49P-50P. doi: 10.1042/bj1290049pb.
7
6(p-Hydroxyphenylazo)-uracil: a reversible, selective inhibitor of the replication of deoxyribonucleic acid of staphylococcal bacteriophage P11-M15.6（对羟基苯偶氮）尿嘧啶：一种葡萄球菌噬菌体P11-M15脱氧核糖核酸复制的可逆性、选择性抑制剂。
J Virol. 1971 Nov;8(5):759-65. doi: 10.1128/JVI.8.5.759-765.1971.
8
Inhibition of a discrete bacterial DNA polymerase by 6-(p-hydroxyphenylazo)-uracil and 6-(p-hydroxyphenylazo-)-isocytosine.6-（对羟基苯偶氮基）尿嘧啶和6-（对羟基苯偶氮基）异胞嘧啶对一种特定细菌DNA聚合酶的抑制作用
Nat New Biol. 1972 Nov 15;240(98):80-2. doi: 10.1038/newbio240080a0.
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Temperature-sensitive mutants affected in DNA synthesis in phage phi29 of Bacillus subtilis.枯草芽孢杆菌噬菌体phi29中DNA合成受影响的温度敏感突变体。
Eur J Biochem. 1972 Dec 4;31(2):367-71. doi: 10.1111/j.1432-1033.1972.tb02542.x.
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A bacteriophage of bacillus subtilis which forms plaques only at temperatures above 50 C. 3. Inhibition of TSP-1-specific deoxyribonucleic acid synthesis at 37 C and 45 C.一种仅在50℃以上温度形成噬菌斑的枯草芽孢杆菌噬菌体。3. 在37℃和45℃时对TSP-1特异性脱氧核糖核酸合成的抑制作用。
J Virol. 1972 Apr;9(4):659-63. doi: 10.1128/JVI.9.4.659-663.1972.

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本文引用的文献

1
TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.脱氧核糖核酸对枯草芽孢杆菌生化缺陷菌株的转化
Proc Natl Acad Sci U S A. 1958 Oct 15;44(10):1072-8. doi: 10.1073/pnas.44.10.1072.
2
STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI.大肠杆菌不平衡生长的研究
Proc Natl Acad Sci U S A. 1954 Oct;40(10):885-93. doi: 10.1073/pnas.40.10.885.
3
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
4
A simple membrane fractionation method for determining the distribution of radioactivity in chemical fractions of Bacillus cereus.一种用于测定蜡样芽孢杆菌化学组分中放射性分布的简单膜分级分离方法。
Biochim Biophys Acta. 1960 Jun 17;41:80-8. doi: 10.1016/0006-3002(60)90371-1.
5
TRANSFORMABLE THYMINE-REQUIRING MUTANT OF BACILLUS SUBTILS.枯草芽孢杆菌的可转化胸腺嘧啶需求突变体
J Bacteriol. 1965 Jan;89(1):262-3. doi: 10.1128/jb.89.1.262-263.1965.
6
THE POSSIBLE ROLE OF RECOMBINATION IN THE INFECTION OF COMPETENT BACILLUS SUBTILIS BY BACTERIOPHAGE DEOXYRIBONUCLEIC ACID.重组在噬菌体脱氧核糖核酸感染感受态枯草芽孢杆菌中的可能作用
Virology. 1964 Dec;24:552-62. doi: 10.1016/0042-6822(64)90207-7.
7
ACTINOMYCIN INHIBITION OF RNA SYNTHESIS DIRECTED BY DNA.放线菌素对由DNA指导的RNA合成的抑制作用。
Fed Proc. 1964 Sep-Oct;23:958-64.
8
INDUCIBLE PHAGES OF BACILLUS SUBTILIS.枯草芽孢杆菌的诱导性噬菌体
Biochemistry. 1964 May;3:607-13. doi: 10.1021/bi00893a001.
9
Thymine deficiency and the normal DNA replication cycle. I.胸腺嘧啶缺乏与正常DNA复制周期。I.
J Mol Biol. 1961 Apr;3:144-55. doi: 10.1016/s0022-2836(61)80041-7.
10
Enzymatic synthesis of deoxyribonucleic acid. I. Preparation of substrates and partial purification of an enzyme from Escherichia coli.脱氧核糖核酸的酶促合成。I. 底物的制备及大肠杆菌中一种酶的部分纯化。
J Biol Chem. 1958 Jul;233(1):163-70.

6-（对羟基苯偶氮）尿嘧啶：噬菌体感染的枯草芽孢杆菌中宿主DNA复制的选择性抑制剂。

6-(p-hydroxyphenylazo)-uracil: a selective inhibitor of host DNA replication in phage-infected Bacillus subtilis.

作者信息

Brown N C

出版信息

Proc Natl Acad Sci U S A. 1970 Nov;67(3):1454-61. doi: 10.1073/pnas.67.3.1454.

DOI:10.1073/pnas.67.3.1454
PMID:4992015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283373/
Abstract

The azopyrimidine, 6-(p-hydroxyphenylazo)-uracil, inhibits the replication of bacterial DNA selectively, completely, and reversibly, and has no apparent effects on the metabolism of other cellular macromolecules thus far examined. The mechanism of its action has been investigated in uninfected and phage-infected Bacillus subtilis, and the compound appears to be specific for a host function. In cells infected with virulent phage the synthesis of phage DNA proceeds normally, while residual host DNA synthesis is completely blocked. The drug-sensitive host site retains its sensitivity even after partial disruption of the cell by lysozyme treatment.

摘要

偶氮嘧啶6-(对羟基苯偶氮)-尿嘧啶能选择性、完全且可逆地抑制细菌DNA的复制，并且迄今为止对所检测的其他细胞大分子的代谢没有明显影响。已在未感染和噬菌体感染的枯草芽孢杆菌中研究了其作用机制，该化合物似乎对宿主功能具有特异性。在感染烈性噬菌体的细胞中，噬菌体DNA的合成正常进行，而残留的宿主DNA合成则完全被阻断。即使在用溶菌酶处理使细胞部分裂解后，药物敏感的宿主位点仍保持其敏感性。