Kind L S, Kaushal P K, Drury P
Infect Immun. 1972 Feb;5(2):180-2. doi: 10.1128/iai.5.2.180-182.1972.
Some yeast mannans increased vascular permeability and caused anaphylaxis-like reactions, fatal in some cases, in nonsensitized CFW mice. In SWR mice deficient in the complement system component C5, anaphylactic shock did not develop after the injection of mannans but was readily induced by goat serum after the mice had been sensitized with Bordetella pertussis and goat serum. The observed biological activity of the yeast mannans appears to depend upon the alpha(1 --> 2) and alpha(1 --> 6) linkages in their main chain. Their relative inactivity in C5-deficient mice and the consumption of whole hemolytic complement after their addition to normal mouse serum suggest that yeast mannans may activate late-acting complement components to produce anaphylatoxin from complement components C5 and C3.
某些酵母甘露聚糖可增加血管通透性，并在未致敏的CFW小鼠中引发类过敏反应，在某些情况下是致命的。在缺乏补体系统成分C5的SWR小鼠中，注射甘露聚糖后不会发生过敏性休克，但在用百日咳博德特氏菌和山羊血清致敏后，山羊血清很容易诱导出过敏性休克。观察到的酵母甘露聚糖的生物活性似乎取决于其主链中的α(1→2)和α(1→6)键。它们在C5缺陷小鼠中的相对无活性以及添加到正常小鼠血清后全溶血补体的消耗表明，酵母甘露聚糖可能激活后期补体成分，从补体成分C5和C3产生过敏毒素。
