前列腺素对人T细胞有丝分裂的抑制作用。产生前列腺素的抑制细胞的存在。
Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.
作者信息
Goodwin J S, Bankhurst A D, Messner R P
出版信息
J Exp Med. 1977 Dec 1;146(6):1719-34. doi: 10.1084/jem.146.6.1719.
Abstract
Small amounts of PGE inhibit mitogen-induced [3H]thymidine incorporation in human peripheral lymphocytes. The 50% inhibitory concentration is approximately 10(-7) M, and this is reduced to approximately 10(-8) M when endogenous PGE production is blocked. PGE inhibits PHA- and Con A-stimulated cultures much better than PWM cultures, suggesting a differential effect of PGE on T-cell vs. B-cell function. In vitro blockade of PG synthesis results in approximately 50% increase in [3H]thymidine incorporation in PHA cultures. PGE is produced endogenously in PHA cultures by glass adherent suppressor cells.
摘要
少量前列腺素E（PGE）可抑制有丝分裂原诱导的人外周血淋巴细胞中[3H]胸腺嘧啶核苷的掺入。50%抑制浓度约为10^(-7) M，当内源性PGE生成被阻断时，该浓度降至约10^(-8) M。PGE对PHA和刀豆蛋白A刺激的培养物的抑制作用比对PWM培养物的抑制作用好得多，这表明PGE对T细胞和B细胞功能有不同的影响。体外阻断前列腺素合成会使PHA培养物中[3H]胸腺嘧啶核苷的掺入增加约50%。在PHA培养物中，玻璃黏附抑制细胞可内源性产生PGE。
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