对半抗原的免疫耐受性。I. 用三硝基苯磺酸诱导和维持对三硝基苯基的耐受性
Immunological tolerance to a hapten. I. Induction and maintenance of tolerance to trinitrophenyl with trinitrobenzene sulfonic acid.
作者信息
Fidler J M, Golub E S
出版信息
J Exp Med. 1973 Jan 1;137(1):42-54. doi: 10.1084/jem.137.1.42.
Abstract
Treatment of mice with a nonimmunogenic preparation of free reactive hapten, trinitrobenzene sulfonic acid (TNBS), leads to the induction of a state of tolerance to the hapten, 2,4,6-trinitrophenyl (TNP). This is determined by the lack of response to the haptenic moiety in an immunogenic hapten-carrier conjugate (TNP-SRBC) as assayed both by serum antibody titrations and the hemolytic plaque assay. The tolerance produced is specific for the hapten, since the anticarrier responses are essentially unaltered compared with the control values. The unresponsiveness induced by TNBS treatment is a dose-dependent phenomenon, becoming less complete at lower doses of TNBS. The tolerance is of a definite length, both in its induction phase and in the duration of the established unresponsive state. Tolerance can be maintained and extended, and may also be reentered once escape has been initiated.
摘要
用非免疫原性的游离反应性半抗原三硝基苯磺酸（TNBS）处理小鼠，可诱导对该半抗原2,4,6-三硝基苯基（TNP）的耐受状态。这可通过血清抗体滴定和溶血空斑试验检测，在免疫原性半抗原-载体偶联物（TNP-SRBC）中缺乏对半抗原部分的反应来确定。所产生的耐受对该半抗原具有特异性，因为与对照值相比，抗载体反应基本未改变。TNBS处理诱导的无反应性是一种剂量依赖性现象，在较低剂量的TNBS时变得不那么完全。耐受在其诱导期和已建立的无反应状态持续时间方面都有确定的时长。耐受可以维持和延长，一旦开始逃逸也可能再次进入。
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