骨髓来源淋巴细胞中的免疫耐受。3. 无关免疫原性或“非免疫原性”载体的半抗原缀合物对已致敏B细胞的耐受诱导。
Immunological tolerance in bone marrow-derived lymphocytes. 3. Tolerance induction in primed B cells by hapten conjugates of unrelated immunogenic or "nonimmunogenic" carriers.
作者信息
Katz D H, Hamaoka T, Benacerraf B
出版信息
J Exp Med. 1974 Jun 1;139(6):1464-72. doi: 10.1084/jem.139.6.1464.
Abstract
The present studies were designed to probe the role(s) of T cells in preventing or altering tolerance induction in hapten-specific B cells. This was accomplished by using hapten conjugates of normally immunogenic heterologous carriers to selectively inhibit 2,4-dinitrophenyl (DNP)-primed B cells in adoptive transfer experiments in vivo. The data provide strong indications that one critical role of T-cell participation in humoral responses to antigens is to circumvent the development of a tolerogenic signal that, in the absence of such T-cell function, might otherwise ensue after binding of the antigenic determinants by specific precursor B lymphocytes.
摘要
本研究旨在探究T细胞在预防或改变半抗原特异性B细胞耐受诱导中的作用。这是通过在体内过继转移实验中使用通常具有免疫原性的异源载体的半抗原缀合物来选择性抑制经2,4-二硝基苯基（DNP）致敏的B细胞来实现的。数据提供了有力的证据，表明T细胞参与对抗原的体液反应的一个关键作用是规避致耐受性信号的产生，在没有这种T细胞功能的情况下，特异性前体B淋巴细胞结合抗原决定簇后可能会产生这种信号。
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Immunological tolerance in bone marrow-derived lymphocytes. 3. Tolerance induction in primed B cells by hapten conjugates of unrelated immunogenic or "nonimmunogenic" carriers.骨髓来源淋巴细胞中的免疫耐受。3. 无关免疫原性或“非免疫原性”载体的半抗原缀合物对已致敏B细胞的耐受诱导。
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本文引用的文献
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Kinetic differences in unresponsiveness of thymus and bone marrow cells.胸腺和骨髓细胞无反应性的动力学差异。
Science. 1971 Feb 26;171(3973):813-5. doi: 10.1126/science.171.3973.813.
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Hapten-specific tolerance. Preferential depression of the high affinity antibody response.半抗原特异性耐受。高亲和力抗体应答的优先抑制。
J Exp Med. 1972 Sep 1;136(3):426-38. doi: 10.1084/jem.136.3.426.
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Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten.非抗原性与免疫耐受性：载体在诱导对半抗原的耐受性中的作用。
J Exp Med. 1971 Oct 1;134(4):1046-61. doi: 10.1084/jem.134.4.1046.
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Induction of immunological tolerance by a hapten (DNP) bound to a non-immunogenic protein carrier.通过与非免疫原性蛋白质载体结合的半抗原（二硝基苯酚）诱导免疫耐受。
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Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells.骨髓源性淋巴细胞中的免疫耐受性。I. 抗体形成细胞的半抗原特异性前体细胞失活的细胞内机制的证据。
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