Galanaud P, Aldo-Benson M, Borel Y
J Immunol. 1975 Jan;114(1 Pt 1):141-4.
A primary immune response to normal BDF1 spleen cells was obtained in vitro to the T-independent antigen TNP-T4 coliphage. This anti-TNP response was suppressed by exposing the spleen cells for 6 hr to TNP bound either to isologous or heterologous gamma-globulin. The suppression was hapten specific. In contrast, TNP-albumin conjugates did not induce tolerance in vitro.
在体外获得了对T非依赖性抗原三硝基苯（TNP）-T4噬菌体的正常BDF1脾细胞的初次免疫应答。通过将脾细胞与结合了同源或异源γ球蛋白的TNP接触6小时，这种抗TNP应答受到抑制。这种抑制是半抗原特异性的。相比之下，TNP-白蛋白缀合物在体外不诱导耐受性。
