Sommer H, Gäng V, Heidland A
Klin Wochenschr. 1977 Oct 15;55(20):1019-20. doi: 10.1007/BF01488189.
Animal experiments have shown that malnutrition and protein deficiency states, respectively are associated with elevated tissue ribonuclease (RNase, E.C. 3.1.4.22) activities. The causal intracellular alterations are unknown. Assuming that increased tissue RNase activities are reflected by serum levels, a study was made of the serum RNase activities in 10 healthy controls eating a normal diet (group I), 7 patients on long-term parenteral nutrition (group II), 13 chronic hemodialysis patients (group III), and 9 patients with acute pancreatitis (group IV). In group I the serum RNase activity corresponded to 195.3 + or -58.8 U/ml. A significant (p less than 0.005) elevation was noted in groups II (314.6 +/- 95.3 U/ml) and III (374.1 +/- 102.1 U/ml), no difference being detected in group IV (295.1 +/- 191.9 U/ml).
动物实验表明，营养不良和蛋白质缺乏状态分别与组织核糖核酸酶（RNase，E.C. 3.1.4.22）活性升高有关。其导致细胞内改变的原因尚不清楚。假设血清水平反映了组织核糖核酸酶活性的增加，我们对10名正常饮食的健康对照者（第一组）、7名长期接受肠外营养的患者（第二组）、13名慢性血液透析患者（第三组）和9名急性胰腺炎患者（第四组）的血清核糖核酸酶活性进行了研究。第一组血清核糖核酸酶活性为195.3±58.8 U/ml。第二组（314.6±95.3 U/ml）和第三组（374.1±102.1 U/ml）显著升高（p<0.005），第四组（295.1±191.9 U/ml）未检测到差异。
