聚（乙烯基尿嘧啶）和聚（乙烯基腺嘌呤）对鼠白血病病毒复制的抑制作用。
Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).
作者信息
Pitha P M, Teich N M, Lowy D R, Pitha J
出版信息
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1204-8. doi: 10.1073/pnas.70.4.1204.
Abstract
Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.
摘要
聚（1-乙烯基尿嘧啶）和聚（9-乙烯基腺嘌呤），以及相应的多核苷酸聚（尿苷酸）和聚（腺苷酸），可抑制小鼠胚胎细胞中的急性鼠白血病病毒感染，但它们对辛德毕斯病毒和水疱性口炎病毒的复制没有显著抑制作用。这些聚合物在病毒复制早期添加时作为抑制剂最为有效。还观察到了乙烯基聚合物对鼠白血病病毒病毒粒子中依赖RNA的DNA聚合酶的影响。
相似文献
1
Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).聚（乙烯基尿嘧啶）和聚（乙烯基腺嘌呤）对鼠白血病病毒复制的抑制作用。
Proc Natl Acad Sci U S A. 1973 Apr;70(4):1204-8. doi: 10.1073/pnas.70.4.1204.
2
Effects of polyadenylic acids on functions of murine RNA tumor viruses.聚腺苷酸对鼠RNA肿瘤病毒功能的影响。
J Virol. 1973 Dec;12(6):1216-25. doi: 10.1128/JVI.12.6.1216-1225.1973.
3
Inhibition of oncornavirus functions by 2'-azido polynucleotides.2'-叠氮多核苷酸对致癌病毒功能的抑制作用。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):284-8. doi: 10.1073/pnas.72.1.284.
4
[Macromolecular virostatic substances and their interferon inducing activity].[大分子病毒抑制物质及其干扰素诱导活性]
Arzneimittelforschung. 1971 Sep;21(9):1389-92.
5
Effects of Poly(1-vinyluracil) and Poly(9-vinyladenine) on viral RNA-directed DNA polymerase.聚（1-乙烯基尿嘧啶）和聚（9-乙烯基腺嘌呤）对病毒RNA指导的DNA聚合酶的影响。
Cancer Res. 1976 Apr;36(4):1273-7.
6
Inhibition of RNA directed DNA polymerase of murine leukemia virus by 2'-O-alkylated polyadenylic acids.2'-O-烷基化聚腺苷酸对鼠白血病病毒RNA指导的DNA聚合酶的抑制作用。
Biochem Biophys Res Commun. 1974 Jul 24;59(2):608-15. doi: 10.1016/s0006-291x(74)80023-9.
7
Effects of poly(2'-O-methyladenylic acid) on susceptibility and autogenous immunity to RNA tumor virus oncogenesis in vivo.聚（2'-O-甲基腺苷酸）对体内RNA肿瘤病毒致癌作用的易感性和自身免疫的影响。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3167-71. doi: 10.1073/pnas.71.8.3167.
8
The inhibition by cytosine arabinoside of the replication of murine leukemia and sarcoma viruses in mouse embryo cultures.阿糖胞苷对小鼠胚胎培养物中鼠白血病病毒和肉瘤病毒复制的抑制作用。
Int J Cancer. 1969 Sep 15;4(5):671-7. doi: 10.1002/ijc.2910040513.
9
Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus.利福平及其两种衍生物对感染莫洛尼肉瘤病毒的细胞的影响。
Proc Natl Acad Sci U S A. 1971 Jul;68(7):1441-3. doi: 10.1073/pnas.68.7.1441.
10
Inhibition of the DNA polymerase of Rauscher leukemia virus by single-stranded polyribonucleotides.单链多聚核糖核苷酸对劳氏肉瘤病毒DNA聚合酶的抑制作用
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2198-202. doi: 10.1073/pnas.68.9.2198.
引用本文的文献
1
Effects of poly(2'-O-methyladenylic acid) on susceptibility and autogenous immunity to RNA tumor virus oncogenesis in vivo.聚（2'-O-甲基腺苷酸）对体内RNA肿瘤病毒致癌作用的易感性和自身免疫的影响。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3167-71. doi: 10.1073/pnas.71.8.3167.
2
Inhibition of RNA-dependent DNA polymerase of avian myeloblastosis virus by pyran copolymer.吡喃共聚物对禽成髓细胞瘤病毒的RNA依赖性DNA聚合酶的抑制作用
Proc Natl Acad Sci U S A. 1974 Feb;71(2):367-70. doi: 10.1073/pnas.71.2.367.
3
Effects of polyadenylic acids on functions of murine RNA tumor viruses.聚腺苷酸对鼠RNA肿瘤病毒功能的影响。
J Virol. 1973 Dec;12(6):1216-25. doi: 10.1128/JVI.12.6.1216-1225.1973.
4
Inhibition of vesicular stomatitis virus replication by poly(2'-fluoro-2'-deoxyuridylic acid).聚（2'-氟-2'-脱氧尿苷酸）对水疱性口炎病毒复制的抑制作用
Antimicrob Agents Chemother. 1975 Nov;8(5):544-50. doi: 10.1128/AAC.8.5.544.
5
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid).聚（2-甲硫基肌苷酸）对肿瘤病毒功能的抑制作用
Nucleic Acids Res. 1975 Dec;2(12):2305-13. doi: 10.1093/nar/2.12.2305.
6
Inhibition of oncornavirus functions by 2'-azido polynucleotides.2'-叠氮多核苷酸对致癌病毒功能的抑制作用。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):284-8. doi: 10.1073/pnas.72.1.284.
本文引用的文献
1
Counting actively metabolizing tissue cultured cells.计数活跃代谢的组织培养细胞。
Exp Cell Res. 1957 Oct;13(2):341-7. doi: 10.1016/0014-4827(57)90013-7.
2
Poly(1-vinyluracil): the preparation and interactions with adenosine derivatives.聚（1-乙烯基尿嘧啶）：制备及其与腺苷衍生物的相互作用
Biochim Biophys Acta. 1970 Mar 19;204(1):39-48. doi: 10.1016/0005-2787(70)90488-0.
3
Preparation and properties of poly-9-vinyladenine.聚-9-乙烯基腺嘌呤的制备与性质
Biopolymers. 1970;9(8):965-77. doi: 10.1002/bip.1970.360090809.
4
Inhibition of the DNA polymerase of Rauscher leukemia virus by single-stranded polyribonucleotides.单链多聚核糖核苷酸对劳氏肉瘤病毒DNA聚合酶的抑制作用
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2198-202. doi: 10.1073/pnas.68.9.2198.
5
Polyadenylic acid sequences in the heterogeneous nuclear RNA and rapidly-labeled polyribosomal RNA of HeLa cells: possible evidence for a precursor relationship.海拉细胞异质性核RNA和快速标记的多核糖体RNA中的聚腺苷酸序列：前体关系的可能证据。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1336-40. doi: 10.1073/pnas.68.6.1336.
6
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA.海拉细胞信使核糖核酸中富含腺苷酸的序列及其与DNA中重复位点的可能关系。
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1321-5. doi: 10.1073/pnas.68.6.1321.
7
The specificity of interferon induction in chick embryo cells by helical RNA.螺旋状RNA在鸡胚细胞中诱导干扰素的特异性。
Proc Natl Acad Sci U S A. 1969 May;63(1):160-7. doi: 10.1073/pnas.63.1.160.
8
Selective interference with viral RNA formation in vitro by specific inhibition with synthetic polyribonucleotides.通过合成多聚核糖核苷酸的特异性抑制在体外对病毒RNA形成的选择性干扰。
Proc Natl Acad Sci U S A. 1966 Oct;56(4):1333-8. doi: 10.1073/pnas.56.4.1333.
9
Paper strip method for assaying gradient fractions containing radioactive macromolecules.用于检测含有放射性大分子的梯度级分的纸条法。
Anal Biochem. 1971 Oct;43(2):427-32. doi: 10.1016/0003-2697(71)90272-7.
10
Vinyl analogs of polynucleotides.多核苷酸的乙烯基类似物。
Biochemistry. 1971 Dec 7;10(25):4595-602. doi: 10.1021/bi00801a001.
Zotero 插件