T和B淋巴细胞的体外激活。I. 细菌脂多糖（LPS）对特异性T细胞辅助功能的调节作用。
Activation of T and B lymphocytes in vitro. I. Regulatory influence of bacterial lipopolysaccharide (LPS) on specific T-cell helper function.
作者信息
Armerding D, Katz D H
出版信息
J Exp Med. 1974 Jan 1;139(1):24-43. doi: 10.1084/jem.139.1.24.
Abstract
The present studies were undertaken to analyze the nature of the effect of bacterial lipopolysaccharide (LPS) on antibody production in vitro. We have done this by making comparative studies of the effects of LPS on in vitro primary and secondary antibody responses to soluble hapten-protein conjugates and to particulate and soluble sheep erythrocyte antigens. The results obtained demonstrate that the biological action of LPS in vitro may be predominantly manifested on the function of B lymphocytes or T lymphocytes depending on the conditions employed. In the absence of antigen, LPS appears to act primarily on B lymphocytes. In the presence of antigen, however, the data presented here show that LPS significantly influences specific helper T-cell function and it is this latter influence that is predominantly responsible for the adjuvant effects of LPS on antigen-specific antibody responses.
摘要
本研究旨在分析细菌脂多糖（LPS）对体外抗体产生的影响的本质。我们通过比较LPS对体外针对可溶性半抗原 - 蛋白质缀合物以及颗粒性和可溶性绵羊红细胞抗原的初次和二次抗体反应的影响来进行此项研究。所获得的结果表明，LPS在体外的生物学作用可能根据所采用的条件主要表现在B淋巴细胞或T淋巴细胞的功能上。在没有抗原的情况下，LPS似乎主要作用于B淋巴细胞。然而，在此处呈现的数据中，在有抗原存在的情况下，LPS显著影响特异性辅助性T细胞功能，正是这后一种影响主要导致了LPS对抗原特异性抗体反应的佐剂效应。
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本文引用的文献
1
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J Exp Med. 1962 May 1;115(5):1023-36. doi: 10.1084/jem.115.5.1023.
2
3
Immune responses in vitro. I. Cellular requirements for the immune response by nonprimed and primed spleen cells in vitro.体外免疫反应。I. 体外非致敏和致敏脾细胞免疫反应的细胞需求。
J Exp Med. 1969 Aug 1;130(2):345-64. doi: 10.1084/jem.130.2.345.
4
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
5
6
Requirement of thymus-dependent lymphocytes for potentiation by adjuvants of antibody formation.胸腺依赖性淋巴细胞对佐剂增强抗体形成的需求。
Nature. 1971 Oct 1;233(5318):330-2. doi: 10.1038/233330a0.
7
The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis.利用细菌脂多糖来表明抗体合成的诱导需要两个信号。
J Exp Med. 1973 Sep 1;138(3):699-714. doi: 10.1084/jem.138.3.699.
8
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Transplant Rev. 1972;11:131-77. doi: 10.1111/j.1600-065x.1972.tb00048.x.
9
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