A组虫媒病毒病毒粒子的抗原成分。
Antigenic components of group A arbovirus virions.
作者信息
Dalrymple J M, Vogel S N, Teramoto A Y, Russell P K
出版信息
J Virol. 1973 Nov;12(5):1034-42. doi: 10.1128/JVI.12.5.1034-1042.1973.
Abstract
Three group A arboviruses, Sindbis (SIN), western (WEE) and eastern equine encephalitis (EEE), were selectively degraded with a nonionic detergent to yield a core particle and a soluble envelope component. Antigenic analysis by using radioimmune precipitation techniques revealed marked antigenic similarity among the core particles of the three viruses. The soluble envelope component exhibited antigenic specificity similar to that of intact virions. A close relationship between SIN and WEE envelopes was shown, whereas EEE envelope antigen appeared antigenically specific. These data indicate that nucleocapsids of group A arboviruses contain an antigenic determinant common to the group; the envelope contains virus-specific antigens as well as antigens which relate members of a subgroup.
摘要
三种A组虫媒病毒，即辛德毕斯病毒（SIN）、西部马脑炎病毒（WEE）和东部马脑炎病毒（EEE），用一种非离子去污剂进行选择性降解，产生一个核心颗粒和一个可溶性包膜成分。使用放射免疫沉淀技术进行的抗原分析显示，这三种病毒的核心颗粒之间存在显著的抗原相似性。可溶性包膜成分表现出与完整病毒粒子相似的抗原特异性。结果表明，SIN和WEE包膜之间存在密切关系，而EEE包膜抗原在抗原性上似乎具有特异性。这些数据表明，A组虫媒病毒的核衣壳含有该组共有的抗原决定簇；包膜含有病毒特异性抗原以及与一个亚组成员相关的抗原。
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