果蝇中酪氨酸tRNA与朱红眼突变体抑制之间的可疑关系。
A doubtful relationship between tyrosine tRNA and suppression of the vermilion mutant in Drosophila.
作者信息
Wosnick M A, White B N
出版信息
Nucleic Acids Res. 1977 Nov;4(11):3919-30. doi: 10.1093/nar/4.11.3919.
Abstract
The conditions under which Drosophila melanogaster are grown markedly influence the amount of the hypermodified nucleoside Q found in certain tRNAs. This effect on Q biosynthesis was found in both the wild-type and the suppressor of sable [su(s)2] mutant. Suppressed vermilion flies [su(s)2v; bw] with 78% of the tyrosine tRNA in the Q-lacking (gamma) form had brown eyes indistinguishible from su(s)2v; bw flies with only 6% of the tyrosine tRNA in the gamma form. The proposal that this tRNA is a specific inhibitor or tryptophan pyrrolase in vermilion flies, and that its absence in su(s)2 flies is the mechanism of suppression is not consistent with these results. In addition, the su(s)2 locus does not seem to be primarily responsible for controlling Q biosynthesis as previously suggested.
摘要
黑腹果蝇的生长条件会显著影响某些转运核糖核酸（tRNA）中发现的超修饰核苷Q的含量。在野生型和黑貂抑制基因[su(s)2]突变体中均发现了这种对Q生物合成的影响。抑制型朱红眼果蝇[su(s)2v; bw]中78%的酪氨酸tRNA呈缺乏Q的（γ）形式，其褐眼与仅6%的酪氨酸tRNA呈γ形式的su(s)2v; bw果蝇难以区分。关于这种tRNA是朱红眼果蝇中色氨酸吡咯酶的特异性抑制剂，且其在su(s)2果蝇中缺失是抑制机制的提议与这些结果不一致。此外，su(s)2基因座似乎并不像之前所认为的那样主要负责控制Q的生物合成。
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