对特定强组织相容性同种异体抗原具有反应性的大鼠胸导管淋巴细胞群体中绵羊红细胞特异性辅助活性。
Sheep red blood cell-specific helper activity in rat thoracic duct lymphocyte populations positively selected for reactivity to specific strong histocompatibility alloantigens.
作者信息
Heber-Katz E, Wilson D B
出版信息
J Exp Med. 1976 Mar 1;143(3):701-6. doi: 10.1084/jem.143.3.701.
Abstract
These studies show that positively selected T-cell populations, having enriched reactivity in the mixed lymphocyte interaction and the graft-versus-host reaction to strong alloantigens of a chosen major histocompatibility complex haplotype, also possess helper activity which is quantitatively normal in the generation of primary antibody responses to sheep red blood cells in vitro. Such positively selected populations give a linear dose plaque-forming cells response curve indistinguishable from that seen with normal unselected T-cell populations. These findings imply that T cells reactive to histocompatibility antigens also react to conventional antigens, and the possibility is raised that they may do so by some recognition mechanism involving multiple specificities.
摘要
这些研究表明，经过阳性选择的T细胞群体，在混合淋巴细胞相互作用以及对选定的主要组织相容性复合体单倍型的强同种异体抗原的移植物抗宿主反应中具有增强的反应性，在体外对绵羊红细胞的初次抗体反应产生过程中，其辅助活性在数量上也是正常的。这样经过阳性选择的群体产生的线性剂量噬斑形成细胞反应曲线，与正常未选择的T细胞群体所产生的曲线没有区别。这些发现意味着，对组织相容性抗原具有反应性的T细胞也会对传统抗原产生反应，并且提出了一种可能性，即它们可能通过某种涉及多种特异性的识别机制来实现这一点。
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Sheep red blood cell-specific helper activity in rat thoracic duct lymphocyte populations positively selected for reactivity to specific strong histocompatibility alloantigens.对特定强组织相容性同种异体抗原具有反应性的大鼠胸导管淋巴细胞群体中绵羊红细胞特异性辅助活性。
J Exp Med. 1976 Mar 1;143(3):701-6. doi: 10.1084/jem.143.3.701.
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The frequency of antigen-sensitive cells in tissue transplantation. A commentary on clonal selection.组织移植中抗原敏感细胞的频率。关于克隆选择的评论。
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Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response.大鼠混合淋巴细胞相互作用的定量研究。3. 反应动力学。
J Exp Med. 1968 Nov 1;128(5):1157-81. doi: 10.1084/jem.128.5.1157.
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The life-span and recirculation of marrow-derived small lymphocytes from the rat thoracic duct.大鼠胸导管中骨髓来源的小淋巴细胞的寿命和再循环
J Exp Med. 1972 Feb 1;135(2):185-99. doi: 10.1084/jem.135.2.185.
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A lymph node weight assay for the graft-versus-host activity of rat lymphoid cells.一种用于检测大鼠淋巴细胞移植物抗宿主活性的淋巴结重量测定法。
Transplantation. 1970 Sep;10(3):258-66. doi: 10.1097/00007890-197009000-00007.
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