H-2淋巴细胞定义成分和血清学定义成分在细胞毒性淋巴细胞产生中的作用。
Role of H-2 lymphocyte-defined and serologically-defined components in the generation of cytotoxic lymphocytes.
作者信息
Alter B J, Bach F H
出版信息
J Exp Med. 1974 Nov 1;140(5):1410-5. doi: 10.1084/jem.140.5.1410.
Abstract
The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is determined by lymphocyte-defined (LD) and serologically-defined (SD) antigenic differences present during sensitization. Cells which are activated by LD differences alone are markedly less effective in causing lysis of target cells. This lack of cytotoxicity is shown to be, at least in part, due to the inability of LD differences to allow the efficient generation of cytotoxic lymphocytes. SD antigens not only serve as good targets for CML but are also shown to be important for the generation of cytotoxic lymphocytes during the mixed lymphocyte culture.
摘要
混合淋巴细胞培养中刺激的小鼠脾细胞的细胞介导的溶淋巴细胞能力由致敏过程中存在的淋巴细胞定义（LD）和血清学定义（SD）的抗原差异决定。仅由LD差异激活的细胞在引起靶细胞裂解方面明显效果较差。这种细胞毒性的缺乏至少部分是由于LD差异无法有效地产生细胞毒性淋巴细胞。SD抗原不仅是细胞介导的淋巴细胞溶解（CML）的良好靶标，而且还表明在混合淋巴细胞培养过程中对细胞毒性淋巴细胞的产生很重要。
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