抗体形成细胞和合成无可检测抗体功能的免疫球蛋白的细胞中存在相似的独特型。
Similar idiotypes in antibody-forming cells and in cells synthesizing immunoglobulins without detectable antibody function.
作者信息
Cazenave P A, Ternynck T, Avrameas S
出版信息
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4500-2. doi: 10.1073/pnas.71.11.4500.
Abstract
The occurrence of immunoglobulins with and without antibody specificity and with and without idiotypic specificity was studied, by use of enzyme-labeled antigen and antibodies, in lymph node cells of rabbits immunized with horse-radish peroxidase and hen ovalbumin. Some cells, containing immunoglobulins without detectable antibody function, were shown to contain idiotypes similar to those found in antibody-producing cells.
摘要
利用酶标记抗原和抗体，对用辣根过氧化物酶和鸡卵清蛋白免疫的家兔淋巴结细胞中具有和不具有抗体特异性以及具有和不具有独特型特异性的免疫球蛋白的出现情况进行了研究。一些含有无可检测抗体功能的免疫球蛋白的细胞，被证明含有与产生抗体的细胞中发现的独特型相似的独特型。
相似文献
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Similar idiotypes in antibody-forming cells and in cells synthesizing immunoglobulins without detectable antibody function.抗体形成细胞和合成无可检测抗体功能的免疫球蛋白的细胞中存在相似的独特型。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4500-2. doi: 10.1073/pnas.71.11.4500.
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A comparison of specific antibody and immunoglobulin synthesising immunocytes in peroxidase stimulated lymph nodes.过氧化物酶刺激的淋巴结中特异性抗体和免疫球蛋白合成免疫细胞的比较
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Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function.具有不同抗体功能甚至没有可检测抗体功能的免疫球蛋白组分中存在相似的独特型特异性。
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2616-20. doi: 10.1073/pnas.68.10.2616.
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Antibody against horse radish peroxidase in lymphoid organs.淋巴器官中抗辣根过氧化物酶抗体。
Acta Morphol Neerl Scand. 1972 Dec;10(4):398-9.
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Enzyme-labeled antigen method: histochemical detection of antigen-specific antibody-producing cells in tissue sections of rats immunized with horseradish peroxidase, ovalbumin, or keyhole limpet hemocyanin.酶标抗原法：用辣根过氧化物酶、卵清蛋白或钥孔戚血蓝蛋白免疫大鼠后，对其组织切片中抗原特异性抗体产生细胞进行组织化学检测。
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引用本文的文献
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Intracellular distribution of antibodies in rat lymph node cells during primary response. A kinetic study.初次免疫应答期间大鼠淋巴结细胞内抗体的细胞内分布。一项动力学研究。
Immunology. 1980 Aug;40(4):613-20.
2
Isotype commitment in the in vivo immune responses. I. Antigen-dependent specific and polyclonal plaque-forming cell responses by B lymphocytes induced to extensive proliferation.体内免疫反应中的同种型定向。I. 诱导B淋巴细胞广泛增殖后，其抗原依赖性特异性和多克隆噬斑形成细胞反应。
J Exp Med. 1982 Sep 1;156(3):690-702. doi: 10.1084/jem.156.3.690.
3
Strain differences in the immune response of mice to horseradish peroxidase.小鼠对辣根过氧化物酶免疫反应的品系差异。
Immunology. 1983 Feb;48(2):367-75.
4
The polyclonal expression of immunoglobulin variable region determinants on the membrane of B cells and their precursors.免疫球蛋白可变区决定簇在B细胞及其前体细胞表面的多克隆表达。
Springer Semin Immunopathol. 1980 Aug;3(2):171-211. doi: 10.1007/BF02053975.
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Autoregulation of immune responses via idiotype network interactions.通过独特型网络相互作用实现免疫反应的自身调节。
Microbiol Rev. 1980 Dec;44(4):631-59. doi: 10.1128/mr.44.4.631-659.1980.
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Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti-idiotypic antibodies in rabbits.免疫系统的独特型调节。独特型与在兔中针对抗独特型抗体产生的抗体之间的共同独特型特异性。
J Exp Med. 1979 Jul 1;150(1):184-95. doi: 10.1084/jem.150.1.184.
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Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies.通过诱导抗独特型抗体的抗体来实现免疫系统的独特型调节。
Proc Natl Acad Sci U S A. 1977 Nov;74(11):5126-30. doi: 10.1073/pnas.74.11.5126.
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Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation.多发性骨髓瘤克隆起源的研究。利用个体特异性（独特型）抗体将致癌事件追溯到其在B细胞分化中最早的表达点。
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Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen.抗原特异性辅助细胞在经抗原免疫后使脾脏中总Ig分泌细胞产生类别受限增加的能力。
J Exp Med. 1979 Sep 19;150(3):517-30. doi: 10.1084/jem.150.3.517.
本文引用的文献
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Individual Antigenic Specificity of Isolated Antibodies.分离抗体的个体抗原特异性
Science. 1963 Jun 14;140(3572):1218-9. doi: 10.1126/science.140.3572.1218.
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[A new allotype form of rabbit serum gamma-globulins, apparently associated with antibody function and specificity].[兔血清γ-球蛋白的一种新同种异型形式，显然与抗体功能和特异性相关]
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The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique.注入的辣根过氧化物酶在小鼠肾近端小管吸收的早期阶段：一种新技术的超微结构细胞化学研究
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Quantitative investigations of idiotypic antibodies. I. Analysis of precipitating antibody populations.独特型抗体的定量研究。I. 沉淀抗体群体的分析。
J Exp Med. 1969 Nov 1;130(5):1047-62. doi: 10.1084/jem.130.5.1047.
5
Peroxidase labelled antibody and Fab conjugates with enhanced intracellular penetration.过氧化物酶标记抗体及具有增强细胞内穿透能力的Fab缀合物。
Immunochemistry. 1971 Dec;8(12):1175-9. doi: 10.1016/0019-2791(71)90395-8.
6
Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies.用戊二醛将酶与蛋白质偶联。偶联物用于抗原和抗体的检测。
Immunochemistry. 1969 Jan;6(1):43-52. doi: 10.1016/0019-2791(69)90177-3.
7
Increase in intracellular immunoglobulins in the majority of splenic lymphoid cells after primary immunization.初次免疫后多数脾淋巴细胞内免疫球蛋白增加。
Eur J Immunol. 1974 Feb;4(2):138-45. doi: 10.1002/eji.1830040214.
8
The genetic control of immunoglobulin synthesis.免疫球蛋白合成的遗传控制。
Proc R Soc Lond B Biol Sci. 1966 Nov 22;166(1003):207-21. doi: 10.1098/rspb.1966.0094.
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[Idiotypy of antibodies against human serum albumin in immunized rabbit serum, which are directed against different regions of this antigen].[免疫兔血清中针对人血清白蛋白的抗体的独特型，这些抗体针对该抗原的不同区域]
FEBS Lett. 1973 May 1;31(3):348-54. doi: 10.1016/0014-5793(73)80139-5.
10
[A study of the production of anti-tyrosinase antibodies in rabbits. I. Cellular studies].[家兔抗酪氨酸酶抗体产生的研究。I. 细胞研究]
Ann Immunol (Paris). 1973 Feb;124(1):121-31.
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