抗独特型抗体诱导抗磷酸胆碱抗体的形成。
Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.
作者信息
Trenkner E, Riblet R
出版信息
J Exp Med. 1975 Nov 1;142(5):1121-32. doi: 10.1084/jem.142.5.1121.
Abstract
Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of antibodies that are specific for phosphorylcholine and carry the idiotypic determinants. This induction is dependent on the recognition of carrier determinants on the anti-idiotype antibody by helper T cells. We conclude that receptor antibody molecules on the surface of the precursors of antibody-forming cells deliver the antigenic signal for the induction of these cells.
摘要
抗独特型抗体已被用于在小鼠抗磷酸胆碱反应中模拟抗原，以研究抗体形成细胞前体的诱导过程。我们已经表明，抗独特型抗体与受体抗体分子的相互作用会诱导形成对磷酸胆碱具有特异性并携带独特型决定簇的抗体。这种诱导依赖于辅助性T细胞对抗独特型抗体上载体决定簇的识别。我们得出结论，抗体形成细胞前体表面的受体抗体分子传递了诱导这些细胞的抗原信号。
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