Louis W J, Tabei R, Spector S
Lancet. 1971 Dec 11;2(7737):1283-6. doi: 10.1016/s0140-6736(71)90603-9.
The effect of sodium chloride intake on systolic blood-pressure was studied in genetic hypertensive Wistar rats. In these animals hypertension can develop on a sodium-"free" diet, but the height to which the blood-pressure rises is related to the sodium intake; increasing the amount of potassium in the diet promotes sodium excretion and ameliorates the hypertension. It is suggested that this form of inherited hypertension may be determined by two different sets of autosomal alleles only one of which is sodium-dependent.
在遗传性高血压Wistar大鼠中研究了氯化钠摄入量对收缩压的影响。在这些动物中，即使采用“无钠”饮食，高血压仍可能发生，但血压升高的幅度与钠摄入量有关；增加饮食中钾的含量可促进钠排泄并改善高血压。有人认为，这种遗传性高血压可能仅由两组不同的常染色体等位基因决定，其中只有一组是钠依赖性的。
