黄曲霉毒素B1在体内对膜-核糖体结合的影响。
The effects of aflatoxin B 1 in vivo on membrane--ribosome association.
作者信息
Williams D J, Clark R P, Rabin B R
出版信息
Br J Cancer. 1973 Apr;27(4):283-90. doi: 10.1038/bjc.1973.35.
Abstract
The effects of aflatoxin B(1) on the endoplasmic reticulum of rat liver has been examined in vivo. Electron microscopy has shown a disorganization and degranulation of rough surfaced membrane under these conditions and evidence is presented that this is a primary effect of the toxin, and results from the direct attack of the aflatoxin on the steroid-dependent ribosome binding sites on the membrane. A technique is described by which the presence of degranulated rough membrane may be detected in microsomal preparations.
摘要
已在体内研究了黄曲霉毒素B（1）对大鼠肝脏内质网的影响。电子显微镜显示，在这些条件下，糙面内质网膜出现紊乱和脱颗粒现象，有证据表明这是毒素的主要作用，是黄曲霉毒素直接攻击膜上依赖类固醇的核糖体结合位点所致。本文描述了一种可在微粒体制剂中检测脱颗粒糙面内质网存在的技术。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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CORRESPONDENCE BETWEEN RIBOSOME AGGREGATION PATTERNS IN RAT LIVER HOMOGENATES AND IN ELECTRON MICROGRAPHS FOLLOWING ADMINISTRATION OF ETHIONINE.乙硫氨酸给药后大鼠肝脏匀浆中核糖体聚集模式与电子显微镜图像之间的对应关系。
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Induction of microsomal enzyme synthesis by polycyclic aromatic hydrocarbons of different molecular sizes.不同分子大小的多环芳烃对微粒体酶合成的诱导作用。
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