抗Ia血清对促有丝分裂反应的影响。II. 植物血凝素和刀豆球蛋白A反应性T细胞上Ia标志物的差异表达。
Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.
作者信息
Niederhuber J E, Frelinger J A, Dine M S, Shoffner P, Dugan E, Shreffler D C
出版信息
J Exp Med. 1976 Feb 1;143(2):372-81. doi: 10.1084/jem.143.2.372.
Abstract
Genes mapping in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on a subpopulation of T cells and on most B cells. Specific anti-Ia serum in the presence of rabbit complement removed the splenic T-cell subpopulation responsive to Con-A, but did not affect the response to phytohemagglutinin (PHA) or Leucoagglutinin. Antibodies specific for Ia, H-2K, or H-2D membrane antigens were used without complement to pretreat spleen cells. These antibody pretreated cells responded normally to Con-A and PHA.
摘要
位于H-2复合体I区的基因控制着一个淋巴细胞同种异体抗原（Ia）系统，该系统在T细胞亚群和大多数B细胞上表达。在兔补体存在的情况下，特异性抗Ia血清去除了对刀豆蛋白A（Con-A）有反应的脾T细胞亚群，但不影响对植物血凝素（PHA）或白细胞凝集素的反应。使用针对Ia、H-2K或H-2D膜抗原的特异性抗体，在无补体的情况下预处理脾细胞。这些经抗体预处理的细胞对Con-A和PHA反应正常。
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Effects of anti-Ia sera on mitogenic responses. II. Differential expression of the Ia marker on phytohemagglutinin and concanavalin A-reactive T cells.抗Ia血清对促有丝分裂反应的影响。II. 植物血凝素和刀豆球蛋白A反应性T细胞上Ia标志物的差异表达。
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本文引用的文献
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2
Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.胸腺来源淋巴细胞上Ia（与H-2相关）抗原表达的证据。
J Exp Med. 1974 Nov 1;140(5):1273-84. doi: 10.1084/jem.140.5.1273.
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Serological identification of an Ir-region product.Ir区域产物的血清学鉴定。
Science. 1973 Jul 13;181(4095):167-9. doi: 10.1126/science.181.4095.167.
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New lymphocyte antigen system (Lna) controlled by the Ir region of the mouse H-2 complex.由小鼠H-2复合体的Ir区域控制的新淋巴细胞抗原系统（Lna）。
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2509-14. doi: 10.1073/pnas.70.9.2509.
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Serologically defined and lymphocyte-defined components of the major histocompatibility complex in the mouse.小鼠主要组织相容性复合体的血清学定义成分和淋巴细胞定义成分。
J Exp Med. 1972 Dec 1;136(6):1430-44. doi: 10.1084/jem.136.6.1430.
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A major role for the Ir-1 region of the mouse H-2 complex in the mixed leukocyte reaction.小鼠H-2复合体的Ir-1区域在混合淋巴细胞反应中起主要作用。
Transplant Proc. 1973 Mar;5(1):377-81.
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