血清素摄取抑制剂对肠上皮和结肠直肠癌的影响。
Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas.
作者信息
Tutton P J, Barkla D H
出版信息
Br J Cancer. 1982 Aug;46(2):260-5. doi: 10.1038/bjc.1982.191.
Abstract
Previous studies have shown that in certain tissues, including colonic carcinomas, cell proliferation may be promoted by serotonin, and indirect evidence suggests that the effects of this amine on colonic tumours involves a cellular-uptake mechanism. In the present study, two specific inhibitors of serotonin uptake, Citalopram and Fluoxetine, are examined for their effects on cell proliferation and tumour growth. Each of the agents was found to suppress cell division in dimethylhydrazine-induced colonic tumours in rats, and to retard the growth of 2 out of 3 lines of human colonic tumours propagated as xenografts in immune-deprived mice.
摘要
先前的研究表明，在某些组织中，包括结肠癌细胞，血清素可能会促进细胞增殖，并且间接证据表明这种胺对结肠肿瘤的作用涉及一种细胞摄取机制。在本研究中，检测了两种血清素摄取的特异性抑制剂——西酞普兰和氟西汀——对细胞增殖和肿瘤生长的影响。发现每种药物均可抑制大鼠二甲基肼诱导的结肠肿瘤中的细胞分裂，并延缓在免疫缺陷小鼠中作为异种移植物繁殖的3个人结肠肿瘤细胞系中2个的生长。
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