Suonio E, Tuomisto L, Alhava E
Department of Pharmacology and Toxicology, University of Kuopio, Finland.
Agents Actions. 1994 Jun;41 Spec No:C118-20. doi: 10.1007/BF02007793.
Biogenic amines play an important role in regulating cell proliferation in the normal and neoplastic colon. Elevated histidine decarboxylase (HDC) activity has been measured in human colorectal tumors. H2 antagonists can suppress the growth of colorectal cancer and their inclusion in human therapy has been proposed. We studied the effects of histamine, cimetidine, mepyramine and alpha-fluoromethylhistidine (FMH) on the growth of colorectal tumors in ten patients in the 6-day mouse subrenal capsule assay (SRCA). The effect of the Hic antagonist DPPE was tested in two assays. In summary, a reduction of tumor size was achieved with histamine and DPPE. In addition, significant inhibition of tumor growth was seen in the FMH-treated animals. When pooled by their growth potential, as assessed by the growth of saline-treated controls, FMH and DPPE caused distinct tumor reduction in rapidly growing tumors. In the moderately growing tumors, histamine and mepyramine were the most effective.
生物胺在调节正常结肠和肿瘤性结肠的细胞增殖中起重要作用。在人类结直肠癌中已检测到组氨酸脱羧酶（HDC）活性升高。H2拮抗剂可抑制结直肠癌的生长，并有人提出将其用于人类治疗。我们在10名患者的6天小鼠肾包膜试验（SRCA）中研究了组胺、西咪替丁、美吡拉敏和α-氟甲基组氨酸（FMH）对结直肠肿瘤生长的影响。在两项试验中测试了Hic拮抗剂DPPE的效果。总之，组胺和DPPE使肿瘤大小减小。此外，在FMH处理的动物中可见肿瘤生长受到显著抑制。根据盐水处理对照组的生长情况评估其生长潜力并进行汇总时，FMH和DPPE使快速生长的肿瘤明显缩小。在生长中等的肿瘤中，组胺和美吡拉敏最为有效。
