组织相容性连锁免疫反应性以及对致敏淋巴细胞施加的限制。
Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes.
作者信息
Miller J F, Vadas M A, Whitelaw A, Gamble J, Bernard C
出版信息
J Exp Med. 1977 Jun 1;145(6):1623-8. doi: 10.1084/jem.145.6.1623.
Abstract
Delayed-type hypersensitivity (DTH) transfer to GAT was restricted by the I-A region of the major histocompatibility complex (MHC). Sensitized cells from F1 hybrid mice between responder and nonresponder strains transferred DTH to syngeneic F1 mice and to naive parental strain recipients of the responder but not of the nonresponder haplotypes. These results are interpreted to favor the postulate that the MHC-linked Ir genes exert their effects by coding for components which allow interactions between particular I region gene products and the region to form stable structures immunogenic for DTH T cells.
摘要
迟发型超敏反应（DTH）向谷氨酸-丙氨酸-酪氨酸（GAT）的转移受主要组织相容性复合体（MHC）的I-A区域限制。来自应答者和无应答者品系之间的F1杂种小鼠的致敏细胞将DTH转移至同基因F1小鼠以及应答者单倍型的未致敏亲本品系受体，但不转移至无应答者单倍型的受体。这些结果被解释为支持这样的假设，即与MHC连锁的免疫反应基因（Ir基因）通过编码特定成分发挥作用，这些成分允许特定I区域基因产物与该区域之间相互作用，形成对DTH T细胞具有免疫原性的稳定结构。
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H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.H-2基因复合体限制小鼠迟发型超敏反应的转移。
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