Loew F M, Schiefer B, Laxdal V A, Prasad K, Forsyth G W, Ackman R G, Olfert E D, Bell J M
Nutr Metab. 1978;22(4):201-17. doi: 10.1159/000176217.
Cynomolgus monkeys (Macaca fascicularis) were fed diets containing 25% rapeseed oil (RSO), partially-hydrogenated herring oil (PHHO) or a 3:1 mixture of lard/corn oil as control (CON) for 4 months. The RSO contained approximately 25% of the fatty acids as erucic acid (cis-docos-13-enoic, 22:1w9) while the PHHO contained a similar concentration of mainly cetoleic acid (cis-docos-11-enoic, 22:1w11). The CON contained no 22:1 acids. The monkeys developed the expected myocardial lipidosis, somewhat more pronounced in the RSO than the PHHO group, but small foci of mononuclear cell infiltration, while infrequent, occurred in all three groups. Significant intergroup differences in biochemical or hematologic measurements of serum constituents were an increase in serum cholesterol concentration in the RSO group and an increase in serum glutamicoxaloacetic transaminase activity in both RSO and PHHO groups at certain intervals. The shorter proportion of M. fascicularis life span represented by this experiment may account for the absence of clear intergroup differences such as are reported in rats used in similar studies.
将食蟹猴（食蟹猕猴）分别喂食含25%菜籽油（RSO）、部分氢化鲱鱼油（PHHO）或作为对照的猪油/玉米油3:1混合物（CON）的日粮，持续4个月。RSO含有约25%的脂肪酸为芥酸（顺式二十二碳-13-烯酸，22:1ω9），而PHHO含有类似浓度的主要为鲸蜡烯酸（顺式二十二碳-11-烯酸，22:1ω11）。CON不含22:1酸。这些猴子出现了预期的心肌脂质沉积，在RSO组比PHHO组更为明显，但单核细胞浸润的小病灶在所有三组中均有出现，尽管不常见。血清成分的生化或血液学测量结果显示，组间存在显著差异，RSO组血清胆固醇浓度升高，RSO组和PHHO组在某些时间段血清谷氨酸草酰乙酸转氨酶活性均升高。本实验所代表的食蟹猴寿命较短比例可能是导致未出现类似在类似研究中使用的大鼠所报道的明显组间差异的原因。
