Marquié G
Postgrad Med J. 1978 Feb;54(628):80-5. doi: 10.1136/pgmj.54.628.80.
A study was undertaken to determine the effects of long-term insulin therapy on the development and regression of lipid perturbations and experimental cholesterol atherosclerosis in rabbits: (1) Insulin administration for 15 days significantly reduced plasma lipid levels and free fatty acids in rabbits fed a high-cholesterol diet; it also inhibited the effects of a single dose of cholesterol. Paradoxically, continued insulin treatment led to the reinforcement of lipaemia through the stimulation of mobilization. Insulin administration during the development of atherosclerosis significantly aggravated the fatty infiltration of the aortic tissue and the lesions of the vessels, and also increased the frequency of coronary lesions. (2) In rabbits fed a cholesterol enriched diet during two months and then a normal diet, insulin treatment accelerated the rate of reduction of hypercholesterolaemia, but aggravated the lipid infiltration of the artery walls, and also prevented regression of coronary atherosclerosis.
进行了一项研究，以确定长期胰岛素治疗对家兔脂质紊乱的发展和消退以及实验性胆固醇动脉粥样硬化的影响：（1）对喂食高胆固醇饮食的家兔给予胰岛素15天，可显著降低其血浆脂质水平和游离脂肪酸；还能抑制单剂量胆固醇的作用。矛盾的是，持续的胰岛素治疗通过刺激动员导致血脂血症增强。在动脉粥样硬化发展过程中给予胰岛素，显著加重了主动脉组织的脂肪浸润和血管病变，也增加了冠状动脉病变的发生率。（2）对喂食富含胆固醇饮食两个月然后改为正常饮食的家兔，胰岛素治疗加速了高胆固醇血症的降低速度，但加重了动脉壁的脂质浸润，也阻止了冠状动脉粥样硬化的消退。
