四氧嘧啶在实验性动脉粥样硬化中的保护机制。
The mechanism of alloxan protection in experimental atherosclerosis.
作者信息
COOK D L, MILLS L M, GREEN D M
出版信息
J Exp Med. 1954 Feb;99(2):119-24. doi: 10.1084/jem.99.2.119.
Experiments were performed to compare the effects of cholesterol feeding in (a) control rabbits, (b) alloxan-diabetic rabbits, and (c) rabbits injected with alloxan while the pancreas was temporarily occluded from the circulation. The alloxan-diabetic rabbits consumed significantly higher quantities of cholesterol and food and had serum cholesterol and lipoprotein (S(f) 5-9 and S(f) 16-30) concentrations significantly increased over the control levels. They failed to show a commensurate increase in the degree of atherosclerosis. Rabbits in which the diabetogenic action of alloxan was prevented by temporary occlusion of the pancreas from the circulation during its administration developed grades of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis not significantly different from the controls. The results are interpreted as indicating that the effects of alloxan on tissues other than the pancreas do not protect against experimental atherosclerosis produced by cholesterol feeding.
进行了实验，以比较喂食胆固醇对以下三种兔子的影响：(a) 对照兔；(b) 四氧嘧啶糖尿病兔；(c) 在胰腺暂时阻断血液循环的情况下注射四氧嘧啶的兔子。四氧嘧啶糖尿病兔摄入的胆固醇和食物量显著更高，其血清胆固醇和脂蛋白（S(f) 5 - 9和S(f) 16 - 30）浓度比对照水平显著升高。它们的动脉粥样硬化程度并未相应增加。在注射四氧嘧啶期间通过暂时阻断胰腺血液循环来防止其致糖尿病作用的兔子，其高胆固醇血症、高脂蛋白血症和动脉粥样硬化的程度与对照组相比无显著差异。结果表明，四氧嘧啶对胰腺以外组织的作用并不能预防由喂食胆固醇引起的实验性动脉粥样硬化。
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