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铜与炎症

Copper and inflammation.

作者信息

Whitehouse M W, Walker W R

出版信息

Agents Actions. 1978 Jan;8(1-2):85-90. doi: 10.1007/BF01972407.

DOI:10.1007/BF01972407
PMID:416664
Abstract

Bonta, Sorenson and others have shown that Cu(II) derivatives are effective anti-inflammatory agents. Some chemical and pharmacological properties of Cu(I) and metallic Cu are discussed. Thio complexes of Cu(I) were prepared and shown to be useful anti-inflammatory agents in rats. Hypotheses are stated concerning the possible therapeutic value of copper in its various oxidation states.

摘要

邦塔、索伦森等人已表明,铜(II)衍生物是有效的抗炎剂。本文讨论了铜(I)和金属铜的一些化学和药理性质。制备了铜(I)的硫代配合物,并证明其在大鼠中是有用的抗炎剂。文中阐述了关于铜在其各种氧化态下可能的治疗价值的假设。

相似文献

1
Copper and inflammation.铜与炎症
Agents Actions. 1978 Jan;8(1-2):85-90. doi: 10.1007/BF01972407.
2
Anti-inflammatory properties of a preparation containing low doses of copper, gold and silver.一种含有低剂量铜、金和银的制剂的抗炎特性。
Int J Tissue React. 1990;12(4):251-62.
3
Ambivalent role of copper in inflammatory disorders.
Agents Actions. 1976 Feb;6(1-3):201-6. doi: 10.1007/BF01972209.
4
Copper complexes of non-steroidal antiinflammatory agents: analgesic activity and possible opioid receptor activation.
Agents Actions. 1987 Jun;21(1-2):130-44. doi: 10.1007/BF01974933.
5
[Auranofin and sodium aurothiomalate: a comparative review. I. Physicochemical, pharmacokinetic and pharmacological properties].[金诺芬与硫代苹果酸金钠:比较性综述。I. 物理化学、药代动力学及药理学特性]
Med Clin (Barc). 1985 May 25;84(20):834-9.
6
Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats.水杨酸铜作为关节炎大鼠的抗炎和镇痛剂
Life Sci. 1983 Feb 28;32(9):1023-30. doi: 10.1016/0024-3205(83)90934-7.
7
Lipophilic copper(II) formulations: some correlations between their composition and anti-inflammatory/anti-arthritic activity when applied to the skin of rats.亲脂性铜(II)制剂:应用于大鼠皮肤时其组成与抗炎/抗关节炎活性之间的一些相关性。
Agents Actions. 1982 Apr;12(1-2):225-31. doi: 10.1007/BF01965151.
8
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis.局部用铜吲哚美辛凝胶对骨关节炎大鼠模型炎症参数的影响。
Drug Des Devel Ther. 2015 Mar 12;9:1491-8. doi: 10.2147/DDDT.S79957. eCollection 2015.
9
Anti-inflammatory activity of some copper(II) complexes.某些铜(II)配合物的抗炎活性。
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Synthesis, antiinflammatory and antiarthritic properties of a new tiopronine gold derivative.一种新型硫普罗宁金衍生物的合成、抗炎及抗关节炎特性
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2
Copper regulation of immune response and potential implications for treating orthopedic disorders.铜对免疫反应的调节及其对治疗骨科疾病的潜在意义。
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本文引用的文献

1
Some copper coordination compounds and their antiinflammatory and antiulcer activities.一些铜配合物及其抗炎和抗溃疡活性。
Inflammation. 1976 Jun;1(3):317-31. doi: 10.1007/BF00917871.
2
Microvascular lesions as a target of anti-inflammatory and certain other drugs.微血管病变作为抗炎药及某些其他药物的作用靶点。
Acta Physiol Pharmacol Neerl. 1969 Jun;15(2):188-222.
3
Systemic absorption of intrauterine copper.宫内铜的全身吸收
Biol Trace Elem Res. 2021 Oct;199(10):3918-3938. doi: 10.1007/s12011-020-02505-0. Epub 2021 Jan 6.
4
CuCl PET/CT imaging of mouse muscular injury induced by electroporation.电穿孔诱导小鼠肌肉损伤的氯化亚铜正电子发射断层显像/计算机断层扫描成像
Am J Nucl Med Mol Imaging. 2017 Jan 15;7(1):33-39. eCollection 2017.
5
Wilson disease at a single cell level: intracellular copper trafficking activates compartment-specific responses in hepatocytes.Wilson 病的单细胞水平研究:细胞内铜转运激活肝细胞的区室特异性反应。
J Biol Chem. 2010 Oct 1;285(40):30875-83. doi: 10.1074/jbc.M110.114447. Epub 2010 Jul 20.
6
Anti-inflammatory activity of a dermally applied copper salicylate preparation (Alcusal).一种经皮应用的水杨酸铜制剂(Alcusal)的抗炎活性。
Agents Actions. 1980 Apr;10(1 Pt 2):38-47. doi: 10.1007/BF02024177.
7
Anti-inflammatory properties of copper implants in the rat paw edema: a preliminary study.铜植入物对大鼠爪肿胀的抗炎特性:一项初步研究。
Agents Actions. 1981 Dec;11(6-7):746-9. doi: 10.1007/BF01978800.
8
Antiulcer activities of D-penicillamine copper complexes.
Agents Actions. 1982 Jul;12(3):408-11. doi: 10.1007/BF01965411.
9
Metabolism of intracellular zinc and copper following single and repeated injections of gold sodium thiomalate.单次及重复注射硫代苹果酸金钠后细胞内锌和铜的代谢
Agents Actions. 1983 Jun;13(4):380-8. doi: 10.1007/BF01971493.
10
Copper and inflammation--a possible rationale for the pharmacological manipulation of inflammatory disorders.铜与炎症——炎症性疾病药物治疗的一种可能理论依据。
Agents Actions. 1985 Sep;16(6):504-13. doi: 10.1007/BF01983655.
Science. 1972 Jul 28;177(4046):358-60. doi: 10.1126/science.177.4046.358.
4
Sulfhydryl groups, copper, diphenylamine reaction and some enzymes in the serum of rats with 6-sulfanilamidoindazole arthritis.
Experientia. 1973 Aug 15;29(8):1002-3. doi: 10.1007/BF01930429.
5
Studies on the mode of action of the Copper-T device.铜-T宫内节育器作用机制的研究。
Acta Endocrinol Suppl (Copenh). 1972;169:3-37.
6
Copper homeostasis in the mammalian system.哺乳动物系统中的铜稳态。
Physiol Rev. 1973 Jul;53(3):535-70. doi: 10.1152/physrev.1973.53.3.535.
7
Free radical production by metallic copper.金属铜产生自由基。
Contraception. 1974 Sep;10(3):273-80. doi: 10.1016/0010-7824(74)90005-5.
8
Experimental inflammation induced by naturally occurring microcrystalline calcium salts.由天然存在的微晶钙盐诱导的实验性炎症。
J Rheumatol. 1976 Mar;3(1):54-62.
9
Copper chelates as possible active forms of the antiarthritic agents.
J Med Chem. 1976 Jan;19(1):135-48. doi: 10.1021/jm00223a024.
10
Urinary copper excretion in rheumatoid arthritis.类风湿关节炎患者的尿铜排泄量
Ann Rheum Dis. 1975 Aug;34(4):340-5. doi: 10.1136/ard.34.4.340.