McMurray W, Martin V M, Scudder P, Stocks J, White A G, Dormandy T L
Ann Rheum Dis. 1975 Aug;34(4):340-5. doi: 10.1136/ard.34.4.340.
The pattern of urinary copper excretion in relation to urine osmolality (as shown by series of aliquots of urine) was studied in rheumatoid patients and in control groups. Rheumatoid patients showed an abnormal copper excretion pattern compared with nonrheumatoid subjects. This was not a direct function of the raised serum copper in rheumatoid disease. Measurements based on 24-hour series of aliquots of urine (as distinct from total pooled 24-hour collections) have been shown to be a useful and sensitive method for studying copper excretion patterns.
在类风湿患者和对照组中研究了尿铜排泄模式与尿渗透压的关系（通过一系列尿液等分试样显示）。与非类风湿受试者相比，类风湿患者表现出异常的铜排泄模式。这并非类风湿病中血清铜升高的直接作用。基于24小时尿液等分试样系列（不同于24小时总混合收集）的测量已被证明是研究铜排泄模式的一种有用且敏感的方法。
