Hashimoto T, Blumenthal H J
Appl Environ Microbiol. 1978 Feb;35(2):274-7. doi: 10.1128/aem.35.2.274-277.1978.
The effects of several physical and chemical agents on the survival of Trichophyton mentagrophytes arthrospores were investigated. Although arthrospores of this dermatophyte were highly resistant to chilling and freezing, they were extremely susceptible to moderate heat (above 50 degrees C) and desiccation. This high susceptibility could be significantly reduced when they were dried in the presence of exogenous proteins. These arthrospores were markedly susceptible to glutaraldehyde. They appeared to be significantly more resistant than their hyphal counterparts to common antimycotics such as clotrimazole, griseofulvin, miconazole nitrate, and nystatin. Clinical and epidemiological implications of these observations are discussed.
研究了几种物理和化学试剂对须癣毛癣菌关节孢子存活的影响。尽管这种皮肤癣菌的关节孢子对寒冷和冷冻具有高度抗性,但它们对适度加热(50摄氏度以上)和干燥极为敏感。当它们在外源蛋白质存在下干燥时,这种高敏感性可显著降低。这些关节孢子对戊二醛明显敏感。它们似乎比其菌丝对应物对克霉唑、灰黄霉素、硝酸咪康唑和制霉菌素等常见抗真菌药具有更强的抗性。讨论了这些观察结果的临床和流行病学意义。