淋病奈瑟菌的免疫学和血清学多样性：豚鼠皮下腔室中通过交叉蛋白对淋球菌进行免疫分型
Immunological and serological diversity of Neisseria gonorrhoeae: immunotyping of gonococci by cross-protein in guinea pig subcutaneous chambers.
作者信息
Arko R J, Wong K H, Bullard J C, Logan L C
出版信息
Infect Immun. 1976 Dec;14(6):1293-6. doi: 10.1128/iai.14.6.1293-1296.1976.
Abstract
An in vivo typing system for studying the immunological relationship of gonococcal strains was established. Nine gonococcal strains of proven virulence for guinea pig subcutaneous chambers were selected, and these isolates were used to immunize groups of guinea pigs that were subsequently cross-challenged with graduated numbers of gonococci from these isolates. Resistance to infection was determined by culture of fluid from challenged chambers; results were expressed as the median dose, in colony-forming units, of gonococci required to produce infection in each group of immunized guinea pigs. This information was then used to develop immunotypes of gonococci based on the cross-protection results obtained. Four cross-protecting immunotypes were established from the preliminary nine strains tested.
摘要
建立了一种用于研究淋球菌菌株免疫关系的体内分型系统。选择了9株经证实对豚鼠皮下腔具有毒力的淋球菌菌株，并用这些分离株免疫几组豚鼠，随后用来自这些分离株的不同数量的淋球菌对其进行交叉攻击。通过对受攻击腔室的液体进行培养来确定对感染的抵抗力；结果以每组免疫豚鼠产生感染所需的淋球菌菌落形成单位的中位数剂量表示。然后根据获得的交叉保护结果，利用这些信息开发淋球菌免疫型。从初步测试的9株菌株中建立了4种交叉保护免疫型。
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本文引用的文献
1
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
2
Transfer of gonococcal urethritis from man to chimpanzee. An animal model for gonorrhea.淋菌性尿道炎从人到黑猩猩的传播。一种淋病的动物模型。
JAMA. 1971 Jun 7;216(10):1612-4.
3
Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro.淋病奈瑟菌。二。35个月体外培养期间的菌落变异与致病性
J Bacteriol. 1968 Sep;96(3):596-605. doi: 10.1128/jb.96.3.596-605.1968.
4
Improved medium selective for cultivation of N. gonorrhoeae and N. meningitidis.改良的用于培养淋病奈瑟菌和脑膜炎奈瑟菌的培养基。
Public Health Rep (1896). 1966 Jun;81(6):559-62.
5
Neisseria gonorrhoeae: effects of systemic immunization on resistance of chimpanzees to urethral infection.淋病奈瑟菌：全身免疫对黑猩猩尿道感染抵抗力的影响。
J Infect Dis. 1974 Aug;130(2):160-4. doi: 10.1093/infdis/130.2.160.
6
Studies on gonococcus infection. 3. Correlation of gonococcal colony morphology with infectivity for the chick embryo.淋病奈瑟菌感染研究。3. 淋球菌菌落形态与对鸡胚感染性的相关性。
J Exp Med. 1973 Jan 1;137(1):196-200. doi: 10.1084/jem.137.1.196.
7
Gonorrhoea in the chimpanzee. Infection with laboratory-passed gonococci and by natural transmission.黑猩猩中的淋病。实验室传代淋病奈瑟菌感染及自然传播感染。
Br J Vener Dis. 1972 Jun;48(3):177-8. doi: 10.1136/sti.48.3.177.
8
Neisseria gonorrhoeae: experimental infection of laboratory animals.淋病奈瑟菌：实验动物的感染实验
Science. 1972 Sep 29;177(4055):1200-1. doi: 10.1126/science.177.4055.1200.
9
Implantation and use of a subcutaneous culture chamber in laboratory animals.皮下培养室在实验动物中的植入与应用。
Lab Anim Sci. 1973 Feb;23(1):105-6.
10
Pathogenesis and immunology of experimental gonococcal infection: virulence of colony types of Neisseria gonorrhoeae for chicken embryos.实验性淋球菌感染的发病机制与免疫学：淋病奈瑟菌菌落类型对鸡胚的毒力
Infect Immun. 1973 Dec;8(6):919-24. doi: 10.1128/iai.8.6.919-924.1973.
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