Denman A M, Frenkel E P
Immunology. 1968 Jan;14(1):115-26.
Lymphopenia in rats which had been made tolerant to normal rabbit immunoglobulin G(IgG) was induced by the administration of rabbit anti-rat immunoglobulin G(IgG). The rats were injected with tritiated thymidine ([H] thymidine) and the labelling pattern in lymphoid tissues was studied. The thymus weight decreased with continued lymphopenia and this could be explained by the release of small lymphocytes into the circulation. Lymphopoiesis in the thymus and spleen was not inhibited by anti-lymphocyte globulin. Plasmacytosis was noted in the lymph nodes. These findings support the idea that anti-lymphocyte globulin acts mainly on peripheral lymphocytes and suppresses the immune function mediated by these cells.
对正常兔免疫球蛋白G（IgG）产生耐受的大鼠，通过给予兔抗大鼠免疫球蛋白G（IgG）诱导淋巴细胞减少。给大鼠注射氚标记的胸腺嘧啶核苷（[H]胸腺嘧啶核苷），并研究淋巴组织中的标记模式。随着淋巴细胞持续减少，胸腺重量下降，这可以通过小淋巴细胞释放到循环中来解释。抗淋巴细胞球蛋白并未抑制胸腺和脾脏中的淋巴细胞生成。在淋巴结中观察到浆细胞增多。这些发现支持了抗淋巴细胞球蛋白主要作用于外周淋巴细胞并抑制这些细胞介导的免疫功能这一观点。
