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抗体合成控制的研究。抗体亲和力对其抑制抗体形成能力的影响。

Studies on the control of antibody synthesis. Effect of antibody affinity upon its ability to suppress antibody formation.

作者信息

Walker J G, Siskind G W

出版信息

Immunology. 1968 Jan;14(1):21-8.

PMID:4169723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409249/
Abstract

Suppression of anti-DNP antibody formation by passively administered anti-DNP antibody was studied quantitatively. The ability of an antiserum to suppress antibody formation was found to be related to the affinity of the antibody for the homologous antigenic determinant (ε-DNP-L-lysine), high affinity antibody being capable of causing suppression at far lower concentrations than low affinity antibody. In addition, very low concentrations of high affinity antibody were found to bring about enhancement of antibody formation. The results are discussed with respect to the significance of circulating antibody in the control of antibody synthesis. Partial suppression of antibody formation by a single injection of passive antibody slightly lowered the affinity of the antibody synthesized. The affinity of the antibody synthesized was independent of the affinity of the passive antibody used to bring about partial suppression.

摘要

定量研究了被动给予抗二硝基苯（DNP）抗体对其抗体形成的抑制作用。发现抗血清抑制抗体形成的能力与抗体对同源抗原决定簇（ε-DNP-L-赖氨酸）的亲和力有关，高亲和力抗体能够在远低于低亲和力抗体的浓度下引起抑制。此外，发现极低浓度的高亲和力抗体可导致抗体形成增强。就循环抗体在抗体合成控制中的意义对结果进行了讨论。单次注射被动抗体对抗体形成的部分抑制略微降低了合成抗体的亲和力。合成抗体的亲和力与用于引起部分抑制的被动抗体的亲和力无关。

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