合成Fc肽介导的免疫反应调节。I. 源自人IgG1 CH3结构域序列的23个氨基酸合成肽免疫调节特性的表征。
Synthetic Fc peptide-mediated regulation of the immune response. I. Characterization of the immunomodulating properties of a synthetic 23-amino acid peptide derived from the sequence of the CH3 domain of human IgG1.
作者信息
Morgan E L, Shields J E, Campbell C S, Barton R L, Koppel G A, Weigle W O
出版信息
J Exp Med. 1983 Mar 1;157(3):947-56. doi: 10.1084/jem.157.3.947.
Abstract
A synthetic 23-amino acid peptide derived from the CH3 domain of human IgG1 was found to be a potent adjuvant as well as a polyclonal activator. The Fc peptide was found to enhance human and murine humoral, and T cell-mediated immune responses. Moreover, in vivo administration of Fc peptide enhanced murine natural killer cell activity. The synthetic Fc peptide was found to be more potent, on a molar basis, than native Fc fragments in inducing polyclonal antibody production and potentiating immune responses.
摘要
一种源自人IgG1 CH3结构域的合成23氨基酸肽被发现是一种有效的佐剂以及多克隆激活剂。Fc肽被发现可增强人和小鼠的体液免疫以及T细胞介导的免疫反应。此外，Fc肽的体内给药增强了小鼠自然杀伤细胞的活性。在诱导多克隆抗体产生和增强免疫反应方面，发现合成Fc肽在摩尔基础上比天然Fc片段更有效。
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