抗原竞争研究。
Studies on antigenic competition.
作者信息
Brody N I, Siskind G W
出版信息
J Exp Med. 1969 Oct 1;130(4):821-32. doi: 10.1084/jem.130.4.821.
Abstract
Antigenic competition was studied in a haptenic system. It was found that: (a) The extent of competition is greater when larger doses of antigen are employed. (b) Antigenic competition appears to be independent of the carrier molecule. (c) The affinity of the antibody produced in antigenic competition is approximately equal to the affinity of antibody formed by animals immunized with only one antigen. (d) Antigenic competition only occurs when both antigens are injected so as to drain into the same regional lymph nodes. The results suggest that antigenic competition occurs locally at the site of antigen stimulation and is not mediated by a circulating factor, by tolerance induction, or by suppression due to synthesis of cross-reacting antibodies.
摘要
在一个半抗原系统中研究了抗原竞争。结果发现：(a) 使用较大剂量抗原时，竞争程度更大。(b) 抗原竞争似乎与载体分子无关。(c) 在抗原竞争中产生的抗体的亲和力大约等于仅用一种抗原免疫的动物所形成抗体的亲和力。(d) 只有当两种抗原都注射以便引流到同一局部淋巴结时，才会发生抗原竞争。结果表明，抗原竞争在抗原刺激部位局部发生，不是由循环因子、耐受性诱导或由于交叉反应抗体的合成所致的抑制介导的。
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