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静脉注射硝酸甘油灌注技术——临床意义

Intravenous nitroglycerin perfusion techniques--clinical implications.

作者信息

Hans P, Paris P, Mathot F

出版信息

Intensive Care Med. 1982 Mar;8(2):93-5. doi: 10.1007/BF01694874.

DOI:10.1007/BF01694874
PMID:6804554
Abstract

Two types of intravenous nitroglycerin (NTG) perfusion sets were studied using laboratory techniques. A known concentration of NTG was placed in each of these sets, and an evaluation was made as to the dose of NTG actually received by the patient after passage of the NTG solution through the sets. Set number one consisted of a glass container and polyvinyl chloride (PVC) tubing. After passage through this set, there was a rapid and significant decrease in the NTG concentration, i.e. the dose actually received by the patient is less than the dose theoretically administered. Set number two consisted of a polypropylene syringe and polyethylene tubing. After passage through this set, there was no significant change in the NTG concentration, i.e. the patient receives the full theoretical dose.

摘要

使用实验室技术研究了两种类型的静脉注射硝酸甘油(NTG)灌注装置。将已知浓度的NTG放入每组装置中,并评估NTG溶液通过装置后患者实际接受的NTG剂量。第一组装置由一个玻璃容器和聚氯乙烯(PVC)管组成。NTG溶液通过该组装置后,NTG浓度迅速且显著降低,即患者实际接受的剂量低于理论给药剂量。第二组装置由一个聚丙烯注射器和聚乙烯管组成。NTG溶液通过该组装置后,NTG浓度没有显著变化,即患者接受了全部理论剂量。

相似文献

1
Intravenous nitroglycerin perfusion techniques--clinical implications.静脉注射硝酸甘油灌注技术——临床意义
Intensive Care Med. 1982 Mar;8(2):93-5. doi: 10.1007/BF01694874.
2
Nitroglycerin adsorption to a combination polyvinyl chloride, polyethylene intravenous administration set.硝酸甘油在聚氯乙烯、聚乙烯组合的静脉给药装置上的吸附作用。
Drug Intell Clin Pharm. 1985 Jul-Aug;19(7-8):572-5. doi: 10.1177/106002808501900715.
3
Polyvinylchloride containers do not influence the hemodynamic response to intravenous nitroglycerin.聚氯乙烯容器不会影响静脉注射硝酸甘油后的血流动力学反应。
Can J Hosp Pharm. 1993 Aug;46(4):165-70.
4
Specialized delivery systems for intravenous nitroglycerin. Are they necessary?静脉注射硝酸甘油的专用给药系统。它们有必要吗?
Am J Med. 1984 Jun 22;76(6A):27-37. doi: 10.1016/0002-9343(84)91040-4.
5
Effect of infusion administration set on the delivery rate and plasma concentration of nitroglycerin in dogs.输液给药装置对犬体内硝酸甘油输注速率及血药浓度的影响。
J Pharm Sci. 1985 Jul;74(7):774-6. doi: 10.1002/jps.2600740717.
6
Clinical response to intravenous nitroglycerin infused through polyethylene or polyvinyl chloride tubing.通过聚乙烯或聚氯乙烯管道静脉输注硝酸甘油的临床反应。
Am J Hosp Pharm. 1994 Feb 15;51(4):490-4.
7
[Loss of intravenous nitroglycerin administered with polyvinyl chloride infusion systems].[使用聚氯乙烯输液系统静脉输注硝酸甘油时硝酸甘油的损失]
Med Clin (Barc). 1991 Feb 2;96(4):129-31.
8
Nitroglycerin compatibility with intravenous fluid filters, containers, and administration sets.硝酸甘油与静脉输液过滤器、容器及给药装置的兼容性。
Am J Hosp Pharm. 1980 Feb;37(2):201-5.
9
Effect of a polyethylene-lined administration set on the availability of diazepam injection.带聚乙烯内衬的给药装置对安定注射液可用性的影响。
Am J Hosp Pharm. 1985 Feb;42(2):335-9.
10
Loss of nitroglycerin during passage through two different infusion sets.硝酸甘油在通过两种不同输液器时的损失。
Acta Pharm Nord. 1991;3(3):131-6.

引用本文的文献

1
Intravenous glyceryl trinitrate (nitroglycerin). A review of its pharmacological properties and therapeutic efficacy.静脉注射硝酸甘油。对其药理特性和治疗效果的综述。
Drugs. 1984 Jan;27(1):45-80. doi: 10.2165/00003495-198427010-00003.

本文引用的文献

1
[I.V. infusion of glyceryl trinitrate. Study of the sorption on various plastic containers (author's transl)].[静脉输注硝酸甘油。不同塑料容器吸附情况的研究(作者译)]
J Pharm Belg. 1980 Sep-Oct;35(5):389-93.
2
Kinetic assay of single nitroglycerin tablets.单硝酸甘油片的动力学测定
J Pharm Sci. 1973 Apr;62(4):696-7. doi: 10.1002/jps.2600620441.
3
[Precordial cartography in the acute phase of myocardial infarct. Attempt at limitation of the necrosis by oral and intravenous nitrate derivatives].[心肌梗死急性期的心前区心电图描记。口服及静脉注射硝酸酯类衍生物限制坏死范围的尝试]
Coeur Med Interne. 1976 Jul-Sep;15(3):423-32.
4
Comparison between the effects of nitroprusside and nitroglycerin on ischemic injury during acute myocardial infarction.硝普钠与硝酸甘油对急性心肌梗死期间缺血性损伤影响的比较。
Circulation. 1976 Nov;54(5):766-73. doi: 10.1161/01.cir.54.5.766.
5
Nitroglycerin infusion during coronary-artery surgery.冠状动脉手术期间静脉输注硝酸甘油
Anesthesiology. 1976 Jul;45(1):14-21. doi: 10.1097/00000542-197607000-00004.
6
Intravenous nitroglycerin in acute myocardial infarction.急性心肌梗死中的静脉注射硝酸甘油
Circulation. 1975 Jan;51(1):132-9. doi: 10.1161/01.cir.51.1.132.
7
Stability of nitroglycerin injection determined by gas chromatography.采用气相色谱法测定硝酸甘油注射液的稳定性。
Am J Hosp Pharm. 1978 May;35(5):537-41.
8
Clinical evaluation of intravenous nitroglycerin for neurosurgery.静脉注射硝酸甘油用于神经外科手术的临床评估
J Neurosurg. 1978 May;48(5):704-11. doi: 10.3171/jns.1978.48.5.0704.
9
Loss of nitroglycerin from aqueous solution into plastic intravenous delivery systems.硝酸甘油从水溶液中流失到塑料静脉给药系统中。
J Pharm Sci. 1979 Sep;68(9):1163-6. doi: 10.1002/jps.2600680928.
10
Specific high-performance liquid chromatographic assay for nitroglycerin in dosage forms.剂型中硝酸甘油的特定高效液相色谱测定法。
J Pharm Sci. 1979 Feb;68(2):237-8. doi: 10.1002/jps.2600680230.