大肠杆菌素K。8. 丝裂霉素诱导的大肠杆菌素K的免疫学特性。
Colicin K. 8. The immunological properties of mitomycin-induced colicin K.
作者信息
Tsao S S, Goebel W F
出版信息
J Exp Med. 1969 Dec 1;130(6):1313-35. doi: 10.1084/jem.130.6.1313.
Abstract
Partially purified colicin K (mCol K) has been obtained from cultures of Escherichia coli K235 induced with mitomycin C. Unlike colicin K (Col K) derived from noninduced cultures of E. coli K235, mitomycin-induced colicin K (mCol K) is not associated with the type O-specific antigen of the colicinogenic bacillus. mCol K elicits in rabbits specific antibodies which precipitate and neutralize the homologous bacteriocin. These colicin-specific antibodies are not precipitated by the colicin-O antigen complex derived from noninduced bacteria. Colicin-neutralizing antibodies can be separated by zone electrophoresis into fractions having different electrophoretic mobilities. The antibodies with lower mobility strongly precipitate the homologous antigen mCol K; those with higher mobility neutralize the bacteriocin and form soluble antigen-antibody complexes.
摘要
部分纯化的大肠杆菌素K（mCol K）是从用丝裂霉素C诱导的大肠杆菌K235培养物中获得的。与源自大肠杆菌K235未诱导培养物的大肠杆菌素K（Col K）不同，丝裂霉素诱导的大肠杆菌素K（mCol K）与产大肠杆菌素杆菌的O型特异性抗原无关。mCol K在兔体内引发特异性抗体，这些抗体可沉淀并中和同源细菌素。这些大肠杆菌素特异性抗体不会被源自未诱导细菌的大肠杆菌素-O抗原复合物沉淀。大肠杆菌素中和抗体可通过区带电泳分离成具有不同电泳迁移率的组分。迁移率较低的抗体强烈沉淀同源抗原mCol K；迁移率较高的抗体中和细菌素并形成可溶性抗原-抗体复合物。
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