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抗原受体分子：抗κ轻链抗血清的抑制作用

Antigen receptor molecules: inhibition by antiserum against kappa light chains.

作者信息

Lesley J, Dutton R W

出版信息

Science. 1970 Jul 31;169(3944):487-8. doi: 10.1126/science.169.3944.487.

DOI:10.1126/science.169.3944.487
PMID:4193208
Abstract

Rabbit antiserum against mouse kappa chains, the predominant class of light chains found in mouse immunoglobulins, inhibits the immune response in vitro of mouse spleen cells to erythrocyte antigens. The inhibition becomes irreversible if the mouse spleen cells are treated briefly with both antiserum to kappa chains and complement.

摘要

针对小鼠κ链（小鼠免疫球蛋白中主要的轻链类别）的兔抗血清，可在体外抑制小鼠脾细胞对红细胞抗原的免疫反应。如果用κ链抗血清和补体对小鼠脾细胞进行短暂处理，这种抑制作用将变得不可逆。

相似文献

1
Antigen receptor molecules: inhibition by antiserum against kappa light chains.抗原受体分子：抗κ轻链抗血清的抑制作用
Science. 1970 Jul 31;169(3944):487-8. doi: 10.1126/science.169.3944.487.
2
Inhibition of the immune response of mouse spleen cells to sheep erythrocytes in vitro by anti-immunoglobulin sera.抗免疫球蛋白血清对小鼠脾细胞体外抗绵羊红细胞免疫反应的抑制作用。
Eur J Immunol. 1971 Jun;1(3):157-62. doi: 10.1002/eji.1830010303.
3
Antibody production in vitro. The effects of anti-allotypic serum on the secondary response of rabbit spleen cell suspensions to sheep erythrocytes (SRC).体外抗体产生。抗同种异型血清对兔脾细胞悬液对绵羊红细胞（SRC）二次应答的影响。
Immunology. 1969 Dec;17(6):911-26.
4
Selective inhibition of cells in the immune response by actinomycin D.放线菌素D对免疫反应中细胞的选择性抑制作用。
J Immunol. 1971 Mar;106(3):781-5.
5
Inhibition of in vitro immune response by treatment of spleen cell suspensions with anti-theta serum.用抗θ血清处理脾细胞悬液对体外免疫反应的抑制作用。
Nature. 1970 Jun 27;226(5252):1258-9. doi: 10.1038/2261258a0.
6
Antibody plaque-forming cells in mice immunized with human gamma globulin. I. Technical considerations.用人γ球蛋白免疫的小鼠中的抗体形成细胞。I. 技术要点。
J Immunol. 1971 Mar;106(3):786-92.
7
Further studies on guinea pig and rabbit cytophilic antibodies directed against human serum albumin. 1. The immune response following sensitization with antigen-antibody complexes.对豚鼠和兔抗人血清白蛋白嗜细胞抗体的进一步研究。1. 用抗原-抗体复合物致敏后的免疫反应。
Int Arch Allergy Appl Immunol. 1972;42(3):382-98. doi: 10.1159/000230621.
8
Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro.
Nat New Biol. 1971 Jun 9;231(23):183-4. doi: 10.1038/newbio231183a0.
9
Allogeneic suppression: inhibition of antibody plaque forming cells in vitro by non-sensitized lymphoid cells.同种异体抑制：未致敏淋巴细胞在体外对抗体斑块形成细胞的抑制作用。
Transplant Proc. 1969 Mar;1(1):574-6.
10
Immune response in vitro to Salmonella H-antigens, not affected by anti-theta serum.体外对沙门氏菌H抗原的免疫反应，不受抗θ血清的影响。
J Immunol. 1971 Dec;107(6):1775-7.

引用本文的文献

1
Antigenic promotion. Increase in hapten-specific plaque-forming cells after pre-injection with structurally unrelated macromolecules.抗原促进作用。预先注射结构不相关的大分子后，半抗原特异性空斑形成细胞增加。
J Exp Med. 1971 Sep 1;134(3 Pt 1):693-712. doi: 10.1084/jem.134.3.693.
2
Immunoglobulins on the surface of thymus-derived cells engaged in the initiation of a humoral immune response.参与体液免疫反应起始的胸腺来源细胞表面的免疫球蛋白。
J Exp Med. 1971 Sep 1;134(3 Pt 1):618-29. doi: 10.1084/jem.134.3.618.
3
Surface immunoglobulins on thymus and thymus-derived lymphoid cells.
胸腺及胸腺衍生淋巴细胞上的表面免疫球蛋白
J Exp Med. 1971 Oct 1;134(4):1005-15. doi: 10.1084/jem.134.4.1005.
4
Cellular receptors. effect of anti-alloantiserum on the recognition of transplantation antigens.细胞受体。抗同种异体抗血清对移植抗原识别的影响。
J Exp Med. 1971 Nov 1;134(5):1083-94. doi: 10.1084/jem.134.5.1083.
5
The induction of haemolysin producing cells in vitro: inhibition by antiglobulin antisera.体外溶血素产生细胞的诱导：抗球蛋白抗血清的抑制作用
Immunology. 1971 Jan;20(1):29-36.
6
Immunosuppression of mice injected with heterologous anti-immunoglobulin heavy chain antisera.注射异源抗免疫球蛋白重链抗血清的小鼠的免疫抑制
J Exp Med. 1972 Jun 1;135(6):1316-33. doi: 10.1084/jem.135.6.1316.
7
Surface antigens of immunocompetent cells. 3. In vitro studies of the role of B and T cells in immunological memory.免疫活性细胞的表面抗原。3. B细胞和T细胞在免疫记忆中作用的体外研究。
J Exp Med. 1972 Oct 1;136(4):663-75. doi: 10.1084/jem.136.4.663.
8
Effect of antibodies against immunoglobulins and the theta antigen on the specific and non-specific stimulation of mouse spleen cells in vitro.抗免疫球蛋白和θ抗原的抗体对小鼠脾细胞体外特异性和非特异性刺激的影响。
Immunology. 1972 Feb;22(2):259-66.
9
Immune responses in vitro. IV. Suppression of primary M, G, and A plaque-forming cell responses in mouse spleen cell cultures by class-specific antibody to mouse immunoglobulins.体外免疫反应。IV. 用小鼠免疫球蛋白的类特异性抗体抑制小鼠脾细胞培养物中初级M、G和A斑块形成细胞反应。
J Exp Med. 1972 Mar 1;135(3):675-97. doi: 10.1084/jem.135.3.675.
10
Specific suppression of the antibody response by antibodies to receptors.通过针对受体的抗体对抗体反应进行特异性抑制。
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2701-5. doi: 10.1073/pnas.69.9.2701.